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J Appl Physiol 97: 1543-1548, 2004; doi:10.1152/japplphysiol.00286.2004
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INVITED REVIEW

HIGHLIGHTED TOPICS
Lung Growth and Repair

Alveolus formation: what have we learned from genetic studies?

Cong Yan1,2 and Hong Du3

1Division of Pulmonary Biology, 3Division of Human Genetics, and 2The Graduate Program for Molecular and Developmental Biology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, The University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039

The respiratory system has two basic functions: air exchange and pathogen clearance. The conducting airway and alveolar parenchyma are the basic structures to fulfill these functions during respiratory cycles. In humans, there are ~40 cell types in the lung that coordinately work together through various structural and signaling molecules. These molecules are vital for maintaining normal lung functions in response to environmental changes. Aberrant expression of these molecules can jeopardize human health and cause various pulmonary diseases. In this article, we will review some recent progress made in the pulmonary field, using genetic animal model systems to elucidate molecular mechanisms that are important for alveolar formation and lung diseases.

alveolar formation; signaling molecules; animal models


Address for reprint requests and other correspondence: C. Yan, Cincinnati Children's Hospital Medical Center, Division of Pulmonary Biology, 3333 Burnet Ave., Cincinnati, OH 45229-3039 (E-mail: cong.yan{at}cchmc.org).




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