HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 97/1/72    most recent 01087.2003v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (8) Citing Articles via Google Scholar Google Scholar Articles by Heled, Y. Articles by Shapiro, Y. Search for Related Content PubMed PubMed Citation Articles by Heled, Y. Articles by Shapiro, Y.

Human ACE I/D polymorphism is associated with individual differences in exercise heat tolerance

¹Heller Institute of Medical Research, and the ²Danek Gartner Institute of Human Genetics, Tel Aviv University, Sheba Medical Center, Tel Hashomer 52621, Israel

Submitted 7 October 2003 ; accepted in final form 20 February 2004

We hypothesized that there is an association between the angiotensin I-converting enzyme (ACE) insertion (I)/deletion (D) polymorphism with the variability in exercise heat tolerance in humans. Fifty-eight Caucasian men were exposed to a 2-h exercise heat-tolerance test. We analyzed the association between their heat-tolerance levels with the ACE DD (n = 25) and I+ (n = 33) genotypes and with various anthropometrical parameters and aerobic fitness. It was found that the relative changes in body core temperature, heat storage, and heart rate during the 120-min exposure to exercise heat stress was consistently lower in the I+ genotype group compared with the DD genotype group (0.8 ± 0.2 vs. 1 ± 0.1°C, P < 0.05; 17.7 ± 1.8 vs. 19.8 ± 1.3 W/M², P < 0.05; and 33 ± 7 vs. 44 ± 5 beats/min, respectively, P = 0.06). No significant association was found between heat strain response and the anthropometrical measurements or aerobic fitness in the various genotype groups. We suggest that the ACE I+ polymorphism may be considered as a possible candidate marker for increased heat tolerance.

angiotensin-converting enzyme polymorphism; thermoregulation; exercise; heat stress; genetics

This article has been cited by other articles:

				Y. Heled, M. S. Bloom, T. J. Wu, Q. Stephens, and P. A. Deuster CM-MM and ACE genotypes and physiological prediction of the creatine kinase response to exercise J Appl Physiol, August 1, 2007; 103(2): 504 - 510. [Abstract] [Full Text] [PDF]

				B Walpole, T D Noakes, M Collins, and R J Trent Growth hormone 1 (GH1) gene and performance and post-race rectal temperature during the South African Ironman triathlon * Commentary Br. J. Sports Med., February 1, 2006; 40(2): 145 - 150. [Abstract] [Full Text] [PDF]