Journal of Applied Physiology
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J Appl Physiol 96: 1899-1908, 2004. First published February 13, 2004; doi:10.1152/japplphysiol.00866.2003
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Effect of tidal volume on distribution of ventilation assessed by synchrotron radiation CT in rabbit

L. Porra,1 S. Monfraix,2,3 G. Berruyer,2 G. Le Duc,2 C. Nemoz,2 W. Thomlinson,2,4 P. Suortti,1,2 A. R. A. Sovijärvi,5 and S. Bayat2

1Department of Physical Sciences, University of Helsinki, FIN 00014 Helsinki, Finland; 2European Synchrotron Radiation Facility, F-38043 Grenoble, France; 3Unité Mixte de Recherche 5525, Centre National de Recherche Scientifique, and Université Joseph Fourier, Grenoble, France; 4Canadian Light Source, Saskatoon, Saskatchewan S7N 0X4, Canada; and 5Department of Clinical Physiology and Nuclear Medicine, Helsinki University Central Hospital, FIN 00029 HUS, Helsinki, Finland

Submitted 15 August 2003 ; accepted in final form 2 January 2004

A respiration-gated synchrotron radiation computed tomography (SRCT) technique, which allows visualization and direct quantification of inhaled stable xenon gas, was used to study the effect of tidal volume (VT) on regional lung ventilation. High-resolution maps (pixel size 0.35 x 0.35 mm) of local washin time constants ({tau}) and regional specific ventilation were obtained in five anesthetized, paralyzed, and mechanically ventilated rabbits in upright body position at the fourth, sixth, and eighth dorsal vertebral levels with a VT from 4.9 ± 0.3 to 7.9 ± 0.4 ml/kg (means ± SE). Increasing VT without an increase in minute ventilation resulted in a proportional increase of mean specific ventilation up to 65% in all studied lung levels and reduced the scattering of washin {tau} values. The {tau} values had log-normal distributions. The results indicate that an increase in VT decreases nonuniformity of intraregional ventilatory gas exchange. The findings suggest that (SRCT) provides a new quantitative tool with high spatial discrimination ability for assessment of changes in peripheral pulmonary gas distribution during mechanical ventilation.

artificial respiration; lung mechanics; pulmonary ventilation; xenon; computed tomography


Address for reprint requests and other correspondence: L. Porra, Dept. of Physical Sciences, POB 64, Univ. of Helsinki, Helsinki FIN 00014, Finland (E-mail: liisa.porra{at}helsinki.fi).




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