HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 96/5/1794    most recent 00567.2002v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by Leslie, S. J. Articles by Webb, D. J. Search for Related Content PubMed PubMed Citation Articles by Leslie, S. J. Articles by Webb, D. J.

Comparison of two plethysmography systems in assessment of forearm blood flow

¹Clinical Pharmacology Unit and Research Centre, The University of Edinburgh, Western General Hospital, Edinburgh, UK EH4 2XU; ²Department of Pharmacology, University of Dresden, D-01307 Dresden, Germany

Submitted 27 June 2002 ; accepted in final form 20 January 2004

Venous occlusion plethysmography is widely used to assess forearm blood flow (FBF). We compared the established Hokanson system (HEC4) with a newly developed Filtrass 2001 system (F2001). The HEC4 uses mercury-in-Silastic strain gauges, whereas F2001 detects volume changes with a nonmercury linear displacement device. The aim of this study was to evaluate the new F2001 against the HEC4 in terms of repeatability and systematic bias. Ten subjects were studied on 4 separate days in random order using either the HEC4 on both arms, the F2001 on both arms, the HEC4 on the right arm with the F2001 on the left, or the F2001 on the right arm and the HEC4 on the left. Stroop's colored word conflict test and postocclusive hyperemia were used to increase FBF, and lower body negative pressure was used to lower FBF. Stroop's colored word conflict test and lower body negative pressure increased (24.6 ± 1.5%, n = 240, P < 0.0001) and decreased (18.7 ± 0.8%, n = 240, P < 0.0001) FBF, respectively. Postocclusive hyperemia after occlusion times of 5, 8, and 13 min substantially increased FBF by 390 ± 86, 756 ± 217, and 851 ± 132%, respectively. Repeatability was not different between the devices (0.10 ± 2.37 vs. -0.47 ± 1.92 l/min, n = 125, P > 0.05), and there was no systematic bias. The F2001 is a newly developed plethysmography system that does not utilize mercury and is suitable for assessing changes of FBF in physiological studies.

validation; Stroop's colored word conflict test; lower body negative pressure

This article has been cited by other articles:

				J. George, E. Carr, J. Davies, J.J.F. Belch, and A. Struthers High-Dose Allopurinol Improves Endothelial Function by Profoundly Reducing Vascular Oxidative Stress and Not by Lowering Uric Acid Circulation, December 5, 2006; 114(23): 2508 - 2516. [Abstract] [Full Text] [PDF]

				P. Pickkers, M. J. Dorresteijn, M. P.W.J.M. Bouw;, J. G. van der Hoeven, and P. Smits In Vivo Evidence for Nitric Oxide-Mediated Calcium-Activated Potassium-Channel Activation During Human Endotoxemia Circulation, August 1, 2006; 114(5): 414 - 421. [Abstract] [Full Text] [PDF]

				O. Jay and G. Havenith Differences in finger skin contact cooling response between an arterial occlusion and a vasodilated condition J Appl Physiol, May 1, 2006; 100(5): 1596 - 1601. [Abstract] [Full Text] [PDF]

				M. J. Dorresteijn, L. T. van Eijk, M. G. Netea, P. Smits, J. G. van der Hoeven, and P. Pickkers Iso-osmolar prehydration shifts the cytokine response towards a more anti-inflammatory balance in human endotoxemia Innate Immunity, October 1, 2005; 11(5): 287 - 293. [Abstract] [PDF]

				D. T. O'Connor, P. E. Cadman, C. Smiley, R. M. Salem, F. Rao, J. Smith, S. D. Funk, S. K. Mahata, M. Mahata, G. Wen, et al. Pancreastatin: Multiple Actions on Human Intermediary Metabolism in Vivo, Variation in Disease, and Naturally Occurring Functional Genetic Polymorphism J. Clin. Endocrinol. Metab., September 1, 2005; 90(9): 5414 - 5425. [Abstract] [Full Text] [PDF]