HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free Online Data Supplement All Versions of this Article: 96/4/1415    most recent 01121.2003v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via ISI Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Zhu, G. Articles by Wolfson, M. R. Search for Related Content PubMed PubMed Citation Articles by Zhu, G. Articles by Wolfson, M. R.

Continuous tracheal gas insufflation during partial liquid ventilation in juvenile rabbits with acute lung injury

¹Department of Respiratory Medicine, Shanghai First People's Hospital, Shanghai, China; ²Departments of Physiology and Pediatrics, Temple University School of Medicine, Temple University Children's Medical Center, Philadelphia, Pennsylvania 19140; and ³Nemours Research Lung Center, Alfred I. duPont Hospital for Children, Wilmington, Delaware 19803

Submitted 16 October 2003 ; accepted in final form 10 December 2003

To examine the hypothesis that combined treatment with tracheal gas insufflation (TGI) and partial liquid ventilation (PLV) may improve pulmonary outcome relative to either treatment alone in acute lung injury (ALI), saline lavage lung injury was induced in 24 anesthetized, ventilated juvenile rabbits that were then randomly assigned to receive (n = 6/group) 1) conventional mechanical ventilation (CMV) alone, 2) continuous TGI at 0.5 l/min, 3) PLV with perfluorochemical liquid, and 4) combined TGI and PLV (TGI + PLV), and subsequently ventilated with minimized pressures and tidal volume (VT) to keep arterial PO₂ (Pa_O2) >100 Torr and arterial PCO₂ (Pa_CO2) at 45-60 Torr for 4 h. Gas exchange, lung mechanics, myeloperoxidase, IL-8, and histomorphometry [including expansion index (EI)] were assessed. The CMV group showed no improvement in lung mechanics and gas exchange; all treated groups had significant increases in compliance, Pa_O2, ventilation efficacy index (VEI), and EI, and decreases in PaCO₂, oxygenation index, physiological dead space-to-VT ratio (VD/VT), myeloperoxidase, and IL-8, relative to the CMV group. TGI resulted in lower peak inspiratory pressure, VT, VD/VT, and greater VEI vs. PLV group; PLV resulted in greater compliance, Pa_O2, and EI vs. TGI. TGI + PLV resulted in decreased peak inspiratory pressure, VT, VD/VT, and increased VEI compared with TGI, improved compliance and EI compared with PLV, and a further increase in Pa_O2 and oxygenation index and a decrease in PaCO₂ vs. either treatment alone. These results indicate that combined treatment of TGI and PLV results in improved pulmonary outcome than either treatment alone in this animal model of ALI.

respiratory distress syndrome; perfluorochemicals; dead space; ventilator-induced lung injury