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Activation of thin-fiber muscle afferents by a P2X agonist in cats

Division of Cardiovascular Medicine, Departments of Internal Medicine and Human Physiology, University of California, Davis, California 95616

Submitted 22 September 2003 ; accepted in final form 29 October 2003

ABSTRACT

The responses of group III and IV triceps surae muscle afferents to intra-arterial injection of ,-methylene ATP (50 µg/kg) was examined in decerebrate cats. We found that this P2X₃ agonist stimulated only three of 18 group III afferents but 7 of 9 group IV afferents (P < 0.004). The three group III afferents stimulated by ,-methylene ATP conducted impulses below 4 m/s. Pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid, a P2-receptor antagonist, prevented the stimulation of these afferents by ,-methylene ATP. We conclude that P2X₃ agonists stimulate only the slowest conducting group III muscle afferents as well as group IV afferents.

adenosine 5'-triphosphate; purines; group III afferents; group IV afferents; metaboreflex; pressor response

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