Journal of Applied Physiology AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 96: 1166-1169, 2004; doi:10.1152/japplphysiol.01020.2003
8750-7587/04 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (18)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hanna, R. L.
Right arrow Articles by Kaufman, M. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hanna, R. L.
Right arrow Articles by Kaufman, M. P.

Activation of thin-fiber muscle afferents by a P2X agonist in cats

Ramy L. Hanna and Marc P. Kaufman

Division of Cardiovascular Medicine, Departments of Internal Medicine and Human Physiology, University of California, Davis, California 95616

Submitted 22 September 2003 ; accepted in final form 29 October 2003

ABSTRACT

The responses of group III and IV triceps surae muscle afferents to intra-arterial injection of {alpha},{beta}-methylene ATP (50 µg/kg) was examined in decerebrate cats. We found that this P2X3 agonist stimulated only three of 18 group III afferents but 7 of 9 group IV afferents (P < 0.004). The three group III afferents stimulated by {alpha},{beta}-methylene ATP conducted impulses below 4 m/s. Pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid, a P2-receptor antagonist, prevented the stimulation of these afferents by {alpha},{beta}-methylene ATP. We conclude that P2X3 agonists stimulate only the slowest conducting group III muscle afferents as well as group IV afferents.

adenosine 5'-triphosphate; purines; group III afferents; group IV afferents; metaboreflex; pressor response


Address for reprint requests and other correspondence: M. P. Kaufman, Division of Cardiovascular Medicine - TB 172, Univ. of California, Davis, One Shields Ave., Davis, CA 95616 (E-mail: mpkaufman{at}ucdavis.edu).




This article has been cited by other articles:


Home page
 J. Physiol.Home page
J. Xing, L. Sinoway, and J. Li
Differential responses of sensory neurones innervating glycolytic and oxidative muscle to protons and capsaicin
J. Physiol., July 1, 2008; 586(13): 3245 - 3252.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Z. Gao, S. Koba, L. Sinoway, and J. Li
20-HETE increases renal sympathetic nerve activity via activation of chemically and mechanically sensitive muscle afferents
J. Physiol., May 15, 2008; 586(10): 2581 - 2591.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. G. Hayes, J. L. McCord, and M. P. Kaufman
Role played by P2X and P2Y receptors in evoking the muscle chemoreflex
J Appl Physiol, February 1, 2008; 104(2): 538 - 541.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. E. Kindig, S. G. Hayes, and M. P. Kaufman
Blockade of purinergic 2 receptors attenuates the mechanoreceptor component of the exercise pressor reflex
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H2995 - H3000.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Z. Gao, J. D. Li, L. I. Sinoway, and J. Li
Effect of muscle interstitial pH on P2X and TRPV1 receptor-mediated pressor response
J Appl Physiol, June 1, 2007; 102(6): 2288 - 2293.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
A. E. Kindig, S. G. Hayes, and M. P. Kaufman
Purinergic 2 receptor blockade prevents the responses of group IV afferents to post-contraction circulatory occlusion
J. Physiol., January 1, 2007; 578(1): 301 - 308.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. Gao, V. Kehoe, J. Xing, L. Sinoway, and J. Li
Temperature modulates P2X receptor-mediated cardiovascular responses to muscle afferent activation
Am J Physiol Heart Circ Physiol, September 1, 2006; 291(3): H1255 - H1261.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. G. Hayes, A. E. Kindig, and M. P. Kaufman
Cyclooxygenase blockade attenuates responses of group III and IV muscle afferents to dynamic exercise in cats
Am J Physiol Heart Circ Physiol, June 1, 2006; 290(6): H2239 - H2246.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. E. Kindig, S. G. Hayes, R. L. Hanna, and M. P. Kaufman
P2 antagonist PPADS attenuates responses of thin fiber afferents to static contraction and tendon stretch
Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1214 - H1219.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
Z. Gao, O. Henig, V. Kehoe, L. I. Sinoway, and J. Li
Vanilloid type 1 receptor and the acid-sensing ion channel mediate acid phosphate activation of muscle afferent nerves in rats
J Appl Physiol, February 1, 2006; 100(2): 421 - 426.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
T. Taguchi, J. Sato, and K. Mizumura
Augmented Mechanical Response of Muscle Thin-Fiber Sensory Receptors Recorded from Rat Muscle-Nerve Preparations In Vitro After Eccentric Contraction
J Neurophysiol, October 1, 2005; 94(4): 2822 - 2831.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L. I. Sinoway and J. Li
A perspective on the muscle reflex: implications for congestive heart failure
J Appl Physiol, July 1, 2005; 99(1): 5 - 22.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.