Journal of Applied Physiology AJP: Lung Cellular and Molecular Physiology
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J Appl Physiol 96: 1039-1044, 2004. First published November 7, 2003; doi:10.1152/japplphysiol.00499.2003
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Recovery of microvascular PO2 during the exercise off-transient in muscles of different fiber type

Paul McDonough, Brad J. Behnke, Timothy I. Musch, and David C. Poole

Departments of Anatomy and Physiology and Kinesiology, Kansas State University, Manhattan, Kansas 66506-5802

Submitted 12 May 2003 ; accepted in final form 5 November 2003

The speed with which muscle energetic status recovers after exercise is dependent on oxidative capacity and vascular O2 pressures. Because vascular control differs between muscles composed of fast- vs. slow-twitch fibers, we explored the possibility that microvascular O2 pressure (PmvO2; proportional to the O2 delivery-to-O2 uptake ratio) would differ during recovery in fast-twitch peroneal (Per: 86% type II) compared with slow-twitch soleus (Sol: 84% type I). Specifically, we hypothesized that, in Per, PmvO2 would be reduced immediately after contractions and would recover more slowly during the off-transient from contractions compared with Sol. The Per and Sol muscles of six female Sprague-Dawley rats (weight = ~220 g) were studied after the cessation of electrical stimulation (120 s; 1 Hz) to compare the recovery profiles of PmvO2. As hypothesized, PmvO2 was lower throughout recovery in Per compared with Sol (end contraction: 13.4 ± 2.2 vs. 20.2 ± 0.9 Torr; end recovery: 24.0 ± 2.4 vs. 27.4 ± 1.2 Torr, Per vs. Sol; P <= 0.05). In addition, the mean response time for recovery was significantly faster for Sol compared with Per (45.1 ± 5.3 vs. 66.3 ± 8.1 s, Sol vs. Per; P < 0.05). Despite these findings, PmvO2 rose progressively in both muscles and at no time fell below end-exercise values. These data indicate that, during the recovery from contractions (which is prolonged in Per), capillary O2 driving pressure (i.e., PmvO2) is reduced in fast-compared with slow-twitch muscle. In conclusion, the results of the present investigation may partially explain the slowed recovery kinetics (phosphocreatine and O2 uptake) found previously in 1) fast- vs. slow-twitch muscle and 2) various patient populations, such as those with congestive heart failure and diabetes mellitus.

recovery from exercise; muscle fiber type; oxygen delivery; oxygen uptake


Address for reprint requests and other correspondence: P. McDonough, Dept. of Internal Medicine, Pulmonary & Critical Care Medicine, H8.130, Univ. of Texas Southwestern Medical Center, Dallas, TX 75390-9034 (E-mail: paul.mcdonough{at}utsouthwestern.edu).




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