Journal of Applied Physiology Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 96: 517-525, 2004. First published September 26, 2003; doi:10.1152/japplphysiol.00799.2003
8750-7587/04 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
96/2/517    most recent
00799.2003v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (24)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Clark, S. A.
Right arrow Articles by Hawley, J. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Clark, S. A.
Right arrow Articles by Hawley, J. A.

Effects of live high, train low hypoxic exposure on lactate metabolism in trained humans

Sally A. Clark,1 Robert J. Aughey,2 Christopher J. Gore,3 Allan G. Hahn,3 Nathan E. Townsend,4 Tahnee A. Kinsman,4 Chin-Moi Chow,4 Michael J. McKenna,2 and John A. Hawley1

1Exercise Metabolism Group, School of Medical Sciences, RMIT University, Victoria 3083; 2Muscle Ions and Exercise Group, School of Human Movement, Recreation and Performance, Centre for Rehabilitation, Exercise and Sports Science, Victoria University of Technology, Victoria 3011; 3Australian Institute of Sport, ACT 2616; 4School of Exercise and Sports Science, The University of Sydney, Sydney, NSW 2141, Australia

Submitted 30 July 2003 ; accepted in final form 23 September 2003

We determined the effect of 20 nights of live high, train low (LHTL) hypoxic exposure on lactate kinetics, monocarboxylate lactate transporter proteins (MCT1 and MCT4), and muscle in vitro buffering capacity ({beta}m) in 29 well-trained cyclists and triathletes. Subjects were divided into one of three groups: 20 consecutive nights of hypoxic exposure (LHTLc), 20 nights of intermittent hypoxic exposure [four 5-night blocks of hypoxia, each interspersed with 2 nights of normoxia (LHTLi)], or control (Con). Rates of lactate appearance (Ra), disappearance (Rd), and oxidation (Rox) were determined from a primed, continuous infusion of L-[U-14C]lactic acid tracer during 90 min of steady-state exercise [60 min at 65% peak O2 uptake (O2 peak) followed by 30 min at 85% O2 peak]. A resting muscle biopsy was taken before and after 20 nights of LHTL for the determination of {beta}m and MCT1 and MCT4 protein abundance. Ra during the first 60 min of exercise was not different between groups. During the last 25 min of exercise at 85% O2 peak, Ra was higher compared with exercise at 65% of O2 peak and was decreased in LHTLc (P < 0.05) compared with the other groups. Rd followed a similar pattern to Ra. Although Rox was significantly increased during exercise at 85% compared with 65% of O2 peak, there were no differences between the three groups or across trials. There was no effect of hypoxic exposure on {beta}m or MCT1 and MCT4 protein abundance. We conclude that 20 consecutive nights of hypoxia exposure decreased whole body Ra during intense exercise in well-trained athletes. However, muscle markers of lactate metabolism and pH regulation were unchanged by the LHTL intervention.

lactate tracer; monocarboxylate transporters; muscle buffering


Address for reprint requests and other correspondence: J. A. Hawley, School of Medical Sciences, RMIT Univ., PO Box 71, Bundoora, Victoria 3083, Australia (E-mail: john.hawley{at}rmit.edu.au).




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. J. Truijens, F. A. Rodriguez, N. E. Townsend, J. Stray-Gundersen, C. J. Gore, and B. D. Levine
The effect of intermittent hypobaric hypoxic exposure and sea level training on submaximal economy in well-trained swimmers and runners
J Appl Physiol, February 1, 2008; 104(2): 328 - 337.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. A. Rodriguez, M. J. Truijens, N. E. Townsend, J. Stray-Gundersen, C. J. Gore, and B. D. Levine
Performance of runners and swimmers after four weeks of intermittent hypobaric hypoxic exposure plus sea level training
J Appl Physiol, November 1, 2007; 103(5): 1523 - 1535.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
F. A. Basset, D. R. Joanisse, F. Boivin, J. St-Onge, F. Billaut, J. Dore, R. Chouinard, G. Falgairette, D. Richard, and M. R. Boulay
Effects of short-term normobaric hypoxia on haematology, muscle phenotypes and physical performance in highly trained athletes
Exp Physiol, March 1, 2006; 91(2): 391 - 402.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. D. Noakes, P. E. di Prampero, C. Capelli, T. Zaobornyj, L. B Valdez, A. Boveris, M. Ashenden, T. W. Secomb, S. Dufour, E. Ponsot, et al.
Comments on Point:Counterpoint "Positive effects of intermittent hypoxia (live high:train low) on exercise performance are/are not mediated primarily by augmented red cell volume"
J Appl Physiol, December 1, 2005; 99(6): 2453 - 2462.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
REBUTTAL FROM DRS. LEVINE AND STRAY-GUNDERSEN
J Appl Physiol, November 1, 2005; 99(5): 2057 - 2057.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2004 by the American Physiological Society.