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J Appl Physiol 96: 19-24, 2004. First published August 29, 2003; doi:10.1152/japplphysiol.00748.2003
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Angiogenic growth factor response to acute systemic exercise in human skeletal muscle

Timothy P. Gavin,1,2 Christopher B. Robinson,1 Robert C. Yeager,1 Justin A. England,1 L. Wiley Nifong,3 and Robert C. Hickner1,2

Departments of 1Exercise and Sport Science, 2Physiology, and 3Surgery, East Carolina University, Greenville, North Carolina 27858

Submitted 18 July 2003 ; accepted in final form 28 August 2003

We investigated whether acute systemic exercise increases vascular endothelial growth factor (VEGF), VEGF receptor (KDR and Flt-1) mRNA, and VEGF protein in sedentary humans. Twelve sedentary subjects were recruited and performed 1 h of acute, cycle ergometer exercise at 50% of maximal oxygen consumption. Muscle biopsies were obtained from the vastus lateralis before exercise and at 0, 2, and 4 h postexercise. Acute exercise significantly increased VEGF mRNA at 2 and 4 h and increased KDR and Flt-1 mRNA at 4 h postexercise. The sustained increase in VEGF mRNA through 4 h and the increases in KDR and Flt-1 at 4 h are different from their respective time course responses in rats. In contrast to the increase in VEGF mRNA postexercise, VEGF protein levels were decreased at 0 h postexercise. These results provide evidence in humans that 1) VEGF, KDR, and Flt-1 mRNA are increased by acute systemic exercise; 2) the time course of the VEGF, KDR, and Flt-1 mRNA responses are different from those previously reported in rats (Gavin TP and Wagner PD. Acta Physiol Scand 175: 201–209, 2002); and 3) VEGF protein is decreased immediately after exercise.

KDR; Flt-1; skeletal muscle capillary supply; time course; vascular endothelial growth factor


Address for reprint requests and other correspondence: T. P. Gavin, 363 Ward Sports Medicine Bldg., East Carolina Univ., Greenville, NC 27858 (E-mail: gavint{at}mail.ecu.edu).




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