HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 95/5/1833    most recent 00359.2003v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (15) Citing Articles via Google Scholar Google Scholar Articles by Flynn, M. G. Articles by Timmerman, K. L. Search for Related Content PubMed PubMed Citation Articles by Flynn, M. G. Articles by Timmerman, K. L.

Toll-like receptor 4 and CD14 mRNA expression are lower in resistive exercise-trained elderly women

¹Wastl Human Performance Laboratory, Purdue University, West Lafayette, Indiana 47906; and ²School of Applied Health and Educational Psychology, Oklahoma State University, Stillwater, Oklahoma 74078

Submitted 10 April 2003 ; revised 23 June 2003

The purpose of this study was to examine the influence of resistive exercise training and hormone status on mRNA expression of toll-like receptor 4 (TLR4), CD14, IL-1, IL-6, and TNF-. Resistive exercise-trained women on "traditional" hormone replacements [hormone replacement therapy (HRT), n = 9], not taking hormones (NHR, n = 6), or taking medications known to influence bone (MIB, n = 7) were compared with untrained subjects not taking supplemental hormones (Con, n = 6). Blood was taken from trained subjects before, immediately after, and 2 h after resistive exercise (same time points for resting Con). TLR4 mRNA expression (RT-PCR) was not different among groups or across time but was significantly (P = 0.044) lower (1.9-fold) when trained groups were collapsed and compared with Con. There was also a significant group effect (P < 0.0001) for TLR4 mRNA when expressed per monocyte. CD14 expression was significantly (P = 0.006) lower (2.3-fold) for training groups collapsed and compared with Con. CD14 mRNA, expressed per monocyte, was significantly lower immediately after resistive exercise for NHR, HRT, and MIB compared with Con. There were few significant effects detected for IL-6, IL-1, and TNF- mRNA, but there was a significant group effect (P < 0.0001) for TNF- mRNA expressed per monocyte (Con > HRT, NHR, MIB). These findings suggest that there may be a resistive exercise training-induced reduction in TLR4/CD14 expression in older women. Further research is needed to determine whether lower TLR4/CD14 could explain the lower LPS-stimulated inflammatory cytokines observed in these women.

lipopolysaccharide; aging; exercise training; inflammatory cytokines

This article has been cited by other articles:

				D. M. Cooper, S. Radom-Aizik, C. Schwindt, and F. Zaldivar Jr. Dangerous exercise: lessons learned from dysregulated inflammatory responses to physical activity J Appl Physiol, August 1, 2007; 103(2): 700 - 709. [Abstract] [Full Text] [PDF]

				M. G. Flynn, B. K. McFarlin, and M. M. Markofski State of the Art Reviews: The Anti-Inflammatory Actions of Exercise Training American Journal of Lifestyle Medicine, May 1, 2007; 1(3): 220 - 235. [Abstract] [PDF]

				B. K. McFarlin, M. G. Flynn, W. W. Campbell, B. A. Craig, J. P. Robinson, L. K. Stewart, K. L. Timmerman, and P. M. Coen Physical activity status, but not age, influences inflammatory biomarkers and toll-like receptor 4. J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2006; 61(4): 388 - 393. [Abstract] [Full Text] [PDF]