Journal of Applied Physiology AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 95: 1617-1622, 2003. First published July 3, 2003; doi:10.1152/japplphysiol.00408.2003
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
95/4/1617    most recent
00408.2003v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Haubold, K. W.
Right arrow Articles by Leinwand, L. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Haubold, K. W.
Right arrow Articles by Leinwand, L. A.

Loss of desmin leads to impaired voluntary wheel running and treadmill exercise performance

Kurt W. Haubold,1 David L. Allen,1 Yassemi Capetanaki,2 and Leslie A. Leinwand1

1Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80309-0347; and 2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030

Submitted 24 April 2003 ; accepted in final form 29 June 2003

We examined voluntary wheel running and forced treadmill running exercise performance of wild-type mice and mice null for the desmin gene. When given access to a cage wheel, desmin null mice spent less time running and ran less far than wild-type mice. Wild-type mice showed a significant training effect with prolonged voluntary wheel running, as evidenced by an increase in mean running speed across the 3-wk exercise period, whereas desmin null mice did not. Desmin null mice also performed less well in acute treadmill stress and endurance tests compared with wild-type mice. We also evaluated serum creatine kinase (CK) activity in wild-type and desmin null mice in response to running. Voluntary running did not result in elevated CK activity in either wild-type or desmin null mice, whereas downhill treadmill running caused significant increases in serum CK activity in both wild-type and desmin null mice. However, the increase in serum CK was significantly less in desmin null mice than in wild-type mice. These results suggest that the lack of desmin adversely affects the ability of mice to engage in both chronic and acute bouts of endurance running exercise but that this decrement in performance is not associated with an increase in serum CK activity.

intermediate filaments; serum creatine kinase; dystrophy; skeletal muscle; muscle damage


Address for reprint requests and other correspondence: L. A. Leinwand, Dept. of Molecular, Cellular, and Developmental Biology, Univ. of Colorado, Campus Box 347, Boulder, CO 80309-0347 (E-mail: leinwand{at}ataqdog.colorado.edu).




This article has been cited by other articles:


Home page
 J. Exp. Biol.Home page
T. H. Meek, B. P. Lonquich, R. M. Hannon, and T. Garland Jr
Endurance capacity of mice selectively bred for high voluntary wheel running
J. Exp. Biol., September 15, 2009; 212(18): 2908 - 2917.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
P. Konieczny, P. Fuchs, S. Reipert, W. S. Kunz, A. Zeold, I. Fischer, D. Paulin, R. Schroder, and G. Wiche
Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms
J. Cell Biol., October 17, 2008; 181(4): 667 - 681.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. A. Wooldridge, C. N. Fortner, B. Lontay, T. Akimoto, R. L. Neppl, C. Facemire, M. B. Datto, A. Kwon, E. McCook, P. Li, et al.
Deletion of the Protein Kinase A/Protein Kinase G Target SMTNL1 Promotes an Exercise-adapted Phenotype in Vascular Smooth Muscle
J. Biol. Chem., April 25, 2008; 283(17): 11850 - 11859.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. R. Stone, A. O'Neill, R. M. Lovering, J. Strong, W. G. Resneck, P. W. Reed, D. M. Toivola, J. A. Ursitti, M. B. Omary, and R. J. Bloch
Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization
J. Cell Sci., November 15, 2007; 120(22): 3999 - 4008.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. T. Woolstenhulme, R. K. Conlee, M. J. Drummond, A. W. Stites, and A. C. Parcell
Temporal response of desmin and dystrophin proteins to progressive resistance exercise in human skeletal muscle
J Appl Physiol, June 1, 2006; 100(6): 1876 - 1882.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
J. M. O. Fernandes
DESMIN LOSS MAKES MICE LAZY
J. Exp. Biol., January 1, 2004; 207(1): 8 - 8.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.