HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free All Versions of this Article: 95/4/1591    most recent 00354.2002v1 Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Harrington, C. Articles by Sullivan, C. E. Search for Related Content PubMed PubMed Citation Articles by Harrington, C. Articles by Sullivan, C. E.

nCPAP improves abnormal autonomic function in at-risk-for-SIDS infants with OSA

¹David Read Laboratory, University of Sydney, and Sydney Children's Hospital, Sydney 2006;²University of Helsinki, Helsinki 00014, Finland; and ³Sydney Children's Hospital, Sydney 2031, Australia

Submitted 22 April 2002 ; accepted in final form 25 April 2003

We evaluated cardiovascular autonomic control and arousability during sleep in infants with obstructive sleep apnea (OSA) before and after 10 ± 4 (mean ± SD) days of treatment with nasal continuous positive airway pressure (nCPAP). Six OSA infants and 12 age-matched control infants were studied with polygraphic sleep studies at the age of 13 ± 4 wk. During the study, 45° head-up tilt tests were performed in slow-wave and rapid eye movement sleep. Blood pressure (BP) and heart rate (HR) were continuously monitored. All OSA infants had decreased initial BP and HR responses, followed by hypotension in two and hypertension in two. OSA infants displayed higher arousal thresholds in response to the tilt in rapid eye movement sleep (P < 0.005) and higher baseline HR (P < 0.05) than controls. nCPAP treatment normalized BP and HR responses as well as arousal thresholds to tilting and stabilized HR levels. OSA in infants may be linked with cardiovascular autonomic control disturbances and decreased arousability during sleep. These defects are improved by control of OSA with nCPAP.

infant; obstructive sleep apnea; blood pressure; heart rate; nasal continuous positive airway pressure; sudden infant death syndrome

This article has been cited by other articles:

				P. Haentjens, A. Van Meerhaeghe, A. Moscariello, S. De Weerdt, K. Poppe, A. Dupont, and B. Velkeniers The Impact of Continuous Positive Airway Pressure on Blood Pressure in Patients With Obstructive Sleep Apnea Syndrome: Evidence From a Meta-analysis of Placebo-Controlled Randomized Trials Arch Intern Med, April 23, 2007; 167(8): 757 - 764. [Abstract] [Full Text] [PDF]

				R. Tauman, L. M. O'Brien, A. Ivanenko, and D. Gozal Obesity Rather Than Severity of Sleep-Disordered Breathing as the Major Determinant of Insulin Resistance and Altered Lipidemia in Snoring Children Pediatrics, July 1, 2005; 116(1): e66 - e73. [Abstract] [Full Text] [PDF]

				T. Kirjavainen, S. Viskari, O. Pitkanen, and E. Jokinen Infants with univentricular heart have reduced heart rate and blood pressure responses to side motion and altered responses to head-up tilt J Appl Physiol, February 1, 2005; 98(2): 518 - 525. [Abstract] [Full Text] [PDF]