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J Appl Physiol 95: 1550-1559, 2003. First published June 20, 2003; doi:10.1152/japplphysiol.01043.2002
8750-7587/03 $5.00
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Level and duration of developmental hyperoxia influence impairment of hypoxic phrenic responses in rats

R. W. Bavis,1 E. B. Olson, Jr.,2 E. H. Vidruk,2 G. E. Bisgard,1 and G. S. Mitchell1

Departments of 1Comparative Biosciences and 2Population Health Sciences, University of Wisconsin, Madison, Wisconsin 53706

Submitted 14 November 2002 ; accepted in final form 16 June 2003

Developmental hyperoxia (1-4 wk of 60% O2) causes long-lasting impairment of hypoxic phrenic responses in rats. We hypothesized that shorter or less severe hyperoxic exposures would produce similar changes. Hypoxic phrenic responses were measured in 3- to 5-mo-old, urethane-anesthetized rats exposed to 60% O2 for postnatal day 1 or week 1 or to 30% O2 for postnatal week 1. Whereas 1 day of 60% O2 had no lasting effects (P > 0.05 vs. control), both 1 wk of 60% O2 and 1 wk of 30% O2 decreased adult hypoxic phrenic responses (P < 0.05 vs. control), although the effects of 30% O2 were smaller. Hypoxic ventilatory responses (expressed as the ratio of minute ventilation to metabolic CO2 production) were also reduced in unanesthetized rats (5-10 mo old) exposed to 1 wk of 60% O2 during development (P < 0.05). An age-dependent increase toward normal hypoxic phrenic responses was observed in rats exposed to 1 wk of 60% O2 (P < 0.05), suggesting a degree of spontaneous recovery not observed after 1 mo of 60% O2. These data indicate that long-lasting effects of developmental hyperoxia depend on the level and duration of hyperoxic exposure.

plasticity; control of breathing; development; chemoreceptor; hypoxia


Address for reprint requests and other correspondence: R. W. Bavis, Biology Dept., Bates College, Carnegie Science Bldg., 44 Campus Ave., Lewiston, ME 04240 (E-mail: rbavis{at}bates.edu).




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