Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
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J Appl Physiol 95: 946-952, 2003; doi:10.1152/japplphysiol.00985.2002
8750-7587/03 $5.00
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Adult carotid chemoafferent responses to hypoxia after 1, 2, and 4 wk of postnatal hyperoxia

G. E. Bisgard,1 E. B. Olson, Jr,2 Z.-Y. Wang,3 R. W. Bavis,1 D. D. Fuller,1 and G. S. Mitchell1

Departments of 1Comparative Biosciences, 2Population Health Sciences, and 3Surgical Sciences, University of Wisconsin, Madison, Wisconsin 53706

Submitted 24 October 2002 ; accepted in final form 12 May 2003

Exposing newborn rats to postnatal hyperoxia (60% O2) for 1-4 wk attenuates the ventilatory and phrenic nerve responses to acute hypoxia in adult rats. The goal of this research was to increase our understanding of the carotid chemoreceptor afferent neural input in this depressed response with different durations of postnatal hyperoxic exposure. Rats were exposed from a few days before birth to 1, 2, or 4 wk of 60% O2 and studied after 3-5 mo in normoxia. The rats were anesthetized with urethane. Whole carotid sinus nerve (CSN) responses to NaCN (40 µg/kg iv), 10 s of asphyxia and acute isocapnic hypoxia (arterial PO2 45 Torr) were determined. Mean CSN responses to stimuli after postnatal hyperoxia were reduced compared with controls. Responses in rats exposed to 1 wk of postnatal hyperoxia were less affected than those exposed to 2 and 4 wk of hyperoxia, which were equivalent to each other. These studies illustrate the importance of normoxia during the first 2 wk of life in development of carotid chemoreceptor afferent function.

asphyxia; sodium cyanide; carotid body development


Address for reprint requests and other correspondence: G. E. Bisgard, Dept. of Comparative Biosciences, Univ. of Wisconsin-Madison, 2015 Linden Dr., Madison, WI 53706 (E-mail: bisgardg{at}svm.vetmed.wisc.edu).




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