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A biphasic model of limb venous compliance: a comparison with linear and exponential models

¹Center for Autonomic and Peripheral Nerve Disorders, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215; and ²Council of Research and Development, CID-001-99, Favaloro University, Buenos Aires, Argentina

Submitted 9 October 2002 ; accepted in final form 6 February 2003

Compliance is not linear within the physiological range of pressures, and linear modeling may not describe venous physiology adequately. Forearm and calf venous compliance were assessed in nine subjects. Venous compliance was modeled by using a biphasic model with high- and low-pressure linear phases separated by a breakpoint. This model was compared with a linear model and several exponential models. The biphasic, linear, and two-parameter exponential models best represented the data. The mean coefficient of determination for the biphasic model was greater than for the linear and exponential models in the calf (biphasic 0.94 ± 0.04, exponential 0.81 ± 0.16, P = not significant; and linear 0.54 ± 0.05, P < 0.05) and forearm (biphasic 0.83 ± 0.17, exponential 0.79 ± 0.15, P = not significant; and linear 0.51 ± 0.06, P < 0.05). The breakpoint pressure in the biphasic model was higher in the calf than the forearm, 34.4 ± 3.9 vs. 29.1 ± 4.5 mmHg, P < 0.05. A biphasic model can describe limb venous compliance and delineate differences in venous physiology at high and low pressures. The steep low-pressure phase of the compliance curve extends to higher pressures in the calf than in the forearm, thereby enlarging the range of pressures over which hemodynamic regulation by the calf venous circulation occurs.

plethysmography; modeling; vascular capacitance

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