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J Appl Physiol 95: 720-727, 2003; doi:10.1152/japplphysiol.00946.2002
8750-7587/03 $5.00
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Physical performance and soleus muscle fiber composition in wild-derived and laboratory inbred mouse strains

Yoshikazu Totsuka,1 Yasumitsu Nagao,2 Takuro Horii,2 Hiromichi Yonekawa,3 Hiroshi Imai,2 Hideo Hatta,4 Yoshiaki Izaike,5 Tomoyuki Tokunaga,5 and Yoriko Atomi4

1YS New Technology Institute, Tochigi 329-0512; 2Laboratory of Reproductive Physiology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502; 3Department of Laboratory Animal Science, The Tokyo Metropolitan Institute of Medical Science, Tokyo 113-8613; 4Department of Life Sciences, The Graduate School of Arts and Sciences, The University of Tokyo, Tokyo 153-8902; and 5Developmental Biology Department, Development and Differentiation Laboratory, National Institute of Agrobiological Sciences, Ibaraki 305-8602, Japan

Submitted 15 October 2002 ; accepted in final form 7 April 2003

We compared four inbred mouse strains in their physical performance, measured as a maximal treadmill running time, characteristics of soleus muscle, anatomic character, and growth. The strains used were Mus musculus domesticus [C57BL/6 (B6) and BALB/c], Mus musculus molossinus (MSM/Ms), and Mus spretus. Maximal running time was significantly different among these four mouse strains. Running time until exhaustion was highest in MSM/Ms and lowest in M. spretus. Maximal times for the laboratory mouse strains were nearly identical. Soleus muscle fiber type and cross-sectional area also differed significantly among the species. In particular, M. spretus was significantly different from the other inbred mouse strains. Growth in the wild-derived inbred mice appeared to be complete earlier than in the laboratory mice, and the body size of the wild strains was about half that of the laboratory strains. From these results, we propose that wild-derived inbred mouse strains are useful models for enhancing phenotypic variation in physical performance and adaptability.

genetic background; maximal running time; growth; Mus spretus


Address for reprint requests and other correspondence: The Graduate School of Arts and Sciences, Dept. of Life Sciences, The Univ. of Tokyo, Tokyo 153-8902, Japan (E-mail: atomi{at}idaten.c.utokyo.ac.jp).




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