HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Free Full Text (PDF) Free Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Shea, J. E. Articles by Mattson, J. P. Search for Related Content PubMed PubMed Citation Articles by Shea, J. E. Articles by Mattson, J. P.

Cortical bone dynamics, strength, and densitometry after induction of emphysema in hamsters

¹Division of Radiobiology, Department of Radiology, University of Utah, Salt Lake City 84108; and ²Department of Exercise and Sport Science, University of Utah, Salt Lake City, Utah 84112; and ³Departments of Kinesiology, Anatomy, and Physiology, Kansas State University, Manhattan, Kansas 66506

Submitted 14 November 2002 ; accepted in final form 21 February 2003

Recent evidence suggests that patients suffering from chronic obstructive pulmonary disease are also at an increased risk of developing osteoporosis. The pathophysiological mechanism(s) linking these progressive diseases is unknown. The goal of this investigation was to determine whether there were alterations in bone mineral density and content, cortical bone structure and strength, and indexes of bone formation and resorption in the elastase-induced emphysematous hamster. At 3 wk after induction of emphysema, the femoral bone mineral content was 8% less (P = 0.026) and the femoral fracture strength was 6% less (P = 0.032) in the emphysematous hamster than in controls. The cortical area was 8.4% less (P = 0.013) and the periosteal mineral appositional rate was 27% less (P = 0.05) than in controls. Additionally, the endocortical eroded surface in the emphysematous group was about twice that in the control group (P = 0.003). Differences in some indexes of bone formation and resorption, paralleled by differences in bone structure and strength, were observed 3 wk after induction of emphysema. These differences in skeletal metabolism and strength may help explain some of the skeletal changes associated with chronic obstructive pulmonary disease in humans.

osteopenia; chronic obstructive pulmonary disease; histomorphometry

This article has been cited by other articles:

				A A Ionescu When should we suspect osteoporosis in patients with chronic airways disease? Chronic Respiratory Disease, January 1, 2005; 2(1): 1 - 2. [PDF]