Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 95: 545-554, 2003. First published April 25, 2003; doi:10.1152/japplphysiol.01051.2002
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
95/2/545    most recent
01051.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (6)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lovering, A. T.
Right arrow Articles by Orem, J. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lovering, A. T.
Right arrow Articles by Orem, J. M.

Ventilatory response of the cat to hypoxia in sleep and wakefulness

Andrew T. Lovering,1 Witali L. Dunin-Barkowski ,1,2 Edward H. Vidruk,3 and John M. Orem1

1Texas Tech University School of Medicine, Department of Physiology, Lubbock, Texas 79430-6551; 2Information Transmission Problems Institute, Russian Academy of Science, Moscow 101447, Russia; and 3University of Wisconsin Medical School, Department of Population Health Sciences, Madison, Wisconsin 53705-2368

Submitted 18 November 2002 ; accepted in final form 23 April 2003

This study characterized ventilation, the airflow waveform, and diaphragmatic activity in response to hypoxia in the intact adult cat during sleep and wakefulness. Exposure to hypoxia for up to 3 h caused sustained hyperventilation during both wakefulness and sleep. Hyperventilation resulted from significant increases in minute ventilation due to increases in both tidal volume and frequency. Diaphragmatic activity changed significantly from augmenting activity with little postinspiratory-inspiratory activity (PIIA) in normoxia to augmenting activity with increased PIIA in hypoxia. The increase in PIIA was least in rapid eye movement sleep. These changes in diaphragmatic activity were associated with changes in airflow waveforms in inspiration and expiration. We conclude that the ventilatory response to hypoxia involves a change in the output of the central pattern generator and that the change is dependent in part on the state of consciousness.

airflow waveform; periodic breathing; diaphragmatic activity; postinspiratory-inspiratory activity; rapid eye movement sleep


Address for reprint requests and other correspondence: J. M. Orem, Texas Tech Univ. School of Medicine, Dept. of Physiology, Lubbock, TX 79430-6551 (E-mail: john.orem{at}ttuhsc.edu).




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Pichon, B. Zhenzhong, F. Favret, G. Jin, H. Shufeng, D. Marchant, J.-P. Richalet, and R.-L. Ge
Long-term ventilatory adaptation and ventilatory response to hypoxia in plateau pika (Ochotona curzoniae): role of nNOS and dopamine
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2009; 297(4): R978 - R987.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. Bollen, M. Bouslama, B. Matrot, Y. Rotrou, G. Vardon, F. Lofaso, O. Van den Bergh, R. D'Hooge, and J. Gallego
Cold stimulates the behavioral response to hypoxia in newborn mice
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1503 - R1511.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
L. S. Segers, S. C. Nuding, T. E. Dick, R. Shannon, D. M. Baekey, I. C. Solomon, K. F. Morris, and B. G. Lindsey
Functional Connectivity in the Pontomedullary Respiratory Network
J Neurophysiol, October 1, 2008; 100(4): 1749 - 1769.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. A. Rybak, R. O'Connor, A. Ross, N. A. Shevtsova, S. C. Nuding, L. S. Segers, R. Shannon, T. E. Dick, W. L. Dunin-Barkowski, J. M. Orem, et al.
Reconfiguration of the Pontomedullary Respiratory Network: A Computational Modeling Study With Coordinated In Vivo Experiments
J Neurophysiol, October 1, 2008; 100(4): 1770 - 1799.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
G. Taccola, L. Secchia, and K. Ballanyi
Anoxic persistence of lumbar respiratory bursts and block of lumbar locomotion in newborn rat brainstem spinal cords
J. Physiol., December 1, 2007; 585(2): 507 - 524.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. T. Lovering, J. J. Fraigne, W. L. Dunin-Barkowski, E. H. Vidruk, and J. M. Orem
Medullary Respiratory Neural Activity During Hypoxia in NREM and REM Sleep in the Cat
J Neurophysiol, February 1, 2006; 95(2): 803 - 810.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.