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CO₂ does not affect passive exercise ventilatory decline

Departments of¹Physiology and²Anaesthesia, University of Toronto, Toronto, Ontario, Canada M5S 1A8

Submitted 20 December 2002 ; accepted in final form 20 February 2003

Breathing increases abruptly at the start of passive exercise, stimulated by afferent feedback from the moving limbs, and declines toward a steady-state hyperpnea as exercise continues. This decline has been attributed to decreased arterial CO₂ levels and adaptation in afferent feedback; however, the relative importance of these two mechanisms is unknown. To address this issue, we compared ventilatory responses to 5 min of passive leg extension exercise performed on 10 awake human subjects (6 men and 4 women) in isocapnic and poikilocapnic conditions. Endtidal PCO₂ decreased significantly during poikilocapnic ( = -1.5 ± 0.5 Torr, P < 0.001), but not isocapnic, passive exercise. Despite this difference, the ventilatory responses to passive exercise were not different between the two conditions. Using the fast changes in ventilation at the start (5.46 ± 0.40 l/min, P < 0.001) and end (3.72 ± 0.33 l/min, P < 0.001) of passive exercise as measures of the drive to breathe from afferent feedback, we found a decline of 68%. We conclude that the decline in ventilation during passive exercise is due to an adaptation in the afferent feedback from the moving limbs, not a decline in CO₂ levels.

afferent feedback; ventilation; tidal volume; breathing frequency

This article has been cited by other articles:

				H. J. Bell, W. Feenstra, and J. Duffin The initial phase of exercise hyperpnoea in humans is depressed during a cognitive task Exp Physiol, May 1, 2005; 90(3): 357 - 365. [Abstract] [Full Text] [PDF]

				H. J. Bell and J. Duffin Respiratory response to passive limb movement is suppressed by a cognitive task J Appl Physiol, December 1, 2004; 97(6): 2112 - 2120. [Abstract] [Full Text] [PDF]