Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 95: 20-25, 2003; doi:10.1152/japplphysiol.00012.2003
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (20)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Walsh, J. H.
Right arrow Articles by Green, D. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Walsh, J. H.
Right arrow Articles by Green, D. J.

TRANSLATIONAL PHYSIOLOGY

Exercise training improves conduit vessel function in patients with coronary artery disease

Jennifer H. Walsh,1 William Bilsborough,2,3 Andrew Maiorana,1,3,4 Matthew Best,3,4 Gerard J. O'Driscoll,1,3,4 Roger R. Taylor,2,4 and Daniel J. Green1,3,4

Departments of 1Human Movement and Exercise Science and 2Medicine, The University of Western Australia, Crawley 6009; and 3Department of Cardiology and 4Cardiac Transplant Unit, Royal Perth Hospital and Western Australia Institute for Medical Research, Perth 6000, Western Australia, Australia

Submitted 7 January 2003 ; accepted in final form 26 March 2003

It is well established that endothelial dysfunction is present in coronary artery disease (CAD), although few studies have determined the effect of training on peripheral conduit vessel function in patients with CAD. A randomized, crossover design determined the effect of 8 wk of predominantly lower limb, combined aerobic and resistance training, in 10 patients with treated CAD. Endothelium-dependent dilation of the brachial artery was determined, by using high-resolution vascular ultrasonography, from flow-mediated vasodilation (FMD) after ischemia. Endothelium-independent vasodilation was measured after administration of glyceryl trinitrate (GTN). Baseline function was compared with that of 10 control subjects. Compared with matched healthy control subjects, FMD and GTN responses were significantly impaired in the untrained CAD patients [3.0 ± 0.8 (SE) vs. 5.8 ± 0.8% and 14.5 ± 1.9 vs. 20.4 ± 1.5%, respectively; both P < 0.05]. Training significantly improved FMD in the CAD patients (from 3.0 ± 0.8 to 5.7 ± 1.1%; P < 0.05) but not responsiveness to GTN (14.5 ± 1.9 vs. 12.1 ± 1.4%; P = not significant). Exercise training improves endothelium-dependent conduit vessel dilation in subjects with CAD, and the effect, evident in the brachial artery, appears to be generalized rather than limited to vessels of exercising muscle beds. These results provide evidence for the benefit of exercise training, as an adjunct to routine therapy, in patients with a history of CAD.

endothelium; blood flow; nitric oxide; ultrasound


Address for reprint requests and other correspondence: D. J. Green, Dept. of Human Movement and Exercise Science, The Univ. of Western Australia, 35 Stirling Highway, Crawley 6009, Western Australia, Australia.




This article has been cited by other articles:


Home page
 J. Clin. Endocrinol. Metab.Home page
E. De Filippis, K. Cusi, G. Ocampo, R. Berria, S. Buck, A. Consoli, and L. J. Mandarino
Exercise-Induced Improvement in Vasodilatory Function Accompanies Increased Insulin Sensitivity in Obesity and Type 2 Diabetes Mellitus
J. Clin. Endocrinol. Metab., December 1, 2006; 91(12): 4903 - 4910.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
K W Lee, A D Blann, K Jolly, G Y H Lip, and on behalf of the BRUM Investigators
Plasma haemostatic markers, endothelial function and ambulatory blood pressure changes with home versus hospital cardiac rehabilitation: the Birmingham Rehabilitation Uptake Maximisation Study
Heart, December 1, 2006; 92(12): 1732 - 1738.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. L. McGowan, A. S. Levy, P. J. Millar, J. C. Guzman, C. A. Morillo, N. McCartney, and M. J. MacDonald
Acute vascular responses to isometric handgrip exercise and effects of training in persons medicated for hypertension
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1797 - H1802.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
J. G. Regensteiner, T. A. Bauer, and J. E.B. Reusch
Rosiglitazone Improves Exercise Capacity in Individuals With Type 2 Diabetes
Diabetes Care, December 1, 2005; 28(12): 2877 - 2883.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
J. A. Blumenthal, A. Sherwood, M. A. Babyak, L. L. Watkins, R. Waugh, A. Georgiades, S. L. Bacon, J. Hayano, R. E. Coleman, and A. Hinderliter
Effects of Exercise and Stress Management Training on Markers of Cardiovascular Risk in Patients With Ischemic Heart Disease: A Randomized Controlled Trial
JAMA, April 6, 2005; 293(13): 1626 - 1634.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. Coats and R. Wadsworth
Marriage of resistance and conduit arteries breeds critical limb ischemia
Am J Physiol Heart Circ Physiol, March 1, 2005; 288(3): H1044 - H1050.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. A. Graham and J. W. E. Rush
Exercise training improves aortic endothelium-dependent vasorelaxation and determinants of nitric oxide bioavailability in spontaneously hypertensive rats
J Appl Physiol, June 1, 2004; 96(6): 2088 - 2096.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.