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1Dipartimento di Scienze e Tecnologie Biomediche, School of Medicine, University of Milan, I-20090 Segrate (MI); 2Istituto di Bioimmagini e Fisiologia Molecolare, CNR, Milan; and 3Dipartimento di Scienze e Tecnologie Biomediche, University of L'Aquila, L'Aquila, Italy
Submitted 29 July 2002 ; accepted in final form 21 February 2003
Near-infrared spectroscopy (NIRS) was utilized to gain insights into the kinetics of oxidative metabolism during exercise transitions. Ten untrained young men were tested on a cycle ergometer during transitions from unloaded pedaling to 5 min of constant-load exercise below (<VT) or above (>VT) the ventilatory threshold. Vastus lateralis oxygenation was determined by NIRS, and pulmonary O2 uptake (
O2) was determined breath-by-breath. Changes in deoxygenated hemoglobin + myoglobin concentration {
[deoxy(Hb + Mb)]} were taken as a muscle oxygenation index. At the transition, [deoxy(Hb + Mb)] was unmodified [time delay (TD)] for 8.9 ± 0.5 s at <VT or 6.4 ± 0.9 s at >VT (both significantly different from 0) and then increased, following a monoexponential function [time constant (
) = 8.5 ± 0.9 s for <VT and 7.2 ± 0.7 s for >VT]. For >VT a slow component of [deoxy(Hb + Mb)] on-kinetics was observed in 9 of 10 subjects after 75.0 ± 14.0 s of exercise. A significant correlation was described between the mean response time (MRT = TD + ) of the primary component of [deoxy(Hb + Mb)] on-kinetics and the of the primary component of the pulmonary O2 on-kinetics. The constant muscle oxygenation during the initial phase of the on-transition indicates a tight coupling between increases in O2 delivery and O2 utilization. The lack of a drop in muscle oxygenation at the transition suggests adequacy of O2 availability in relation to needs.
near-infrared spectroscopy; oxidative metabolism; skeletal muscle; functional evaluation; oxygen uptake kinetics
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