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J Appl Physiol 95: 145-148, 2003. First published February 28, 2003; doi:10.1152/japplphysiol.00471.2002
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Glutamine supplementation further enhances exercise-induced plasma IL-6

N. Hiscock,1,2 E. W. Petersen,1,2 K. Krzywkowski,1,2 J. Boza,4 J. Halkjaer-Kristensen,3 and B. K. Pedersen1,2

1Copenhagen Muscle Research Centre, 2Laboratory of Infectious Diseases, and 3Department of Orthopedic Rehabilitation and Medicine, Rigshospitalet, DK 2100 Copenhagen, Denmark; and 4Néstle Research Centre, CH-1000 Lausanne, Switzerland

Submitted 28 May 2002 ; accepted in final form 20 February 2003

Exercise stimulates the production and release of interleukin-6 (IL-6) from skeletal muscle. Glutamine is also synthesized in skeletal muscle and is involved in protein synthesis within this tissue. During exercise, plasma levels of glutamine decline, and this may affect the concentration of plasma IL-6 via a decrease in IL-6 synthesis and release from muscle. We hypothesized that glutamine supplementation would attenuate the exercise-induced decrease in plasma glutamine concentration and, thus, further enhance levels of plasma IL-6. Eight healthy men participated in a randomized, double-blind, crossover study in which they performed 2 h of cycle ergometry at 75% of peak O2 uptake. They received glutamine, glutamine-rich protein, or placebo supplementation at intervals during and 2 h after exercise. Exercise induced an 11-fold increase in plasma IL-6, which was further enhanced by glutamine (18-fold) and glutamine-rich protein (14-fold) supplementation, administered at doses that attenuated the exercise-induced decrease in plasma glutamine concentration.

skeletal muscle; acute exercise; cytokines


Address for reprint requests and other correspondence: B. K. Pedersen, Copenhagen Muscle Research Centre, Rigshospitalet, Section 7641, Blegdamsvej 9, DK-2100 Copenhagen N, Denmark (E-mail: bkp{at}rh.dk).




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