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J Appl Physiol 94: 2502-2509, 2003; doi:10.1152/japplphysiol.00209.2003
8750-7587/03 $5.00
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Vol. 94, Issue 6, 2502-2509, June 2003

HIGHLIGHTED TOPICS
Genetic Models in Applied Physiology
Invited Review: Functional genomics in the mouse: powerful techniques for unraveling the basis of human development and disease

Clifford W. Bogue

Yale Child Health Research Center, Section of Critical Care and Applied Physiology, Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06519

Now that near-complete DNA sequences of both the mouse and human genomes are available, the next major challenge will be to determine how each of these genes functions, both alone and in combination with other genes in the genome. The mouse has a long and rich history in biological research, and many consider it a model organism for the study of human development and disease. Over the past few years, exciting progress has been made in developing techniques for chromosome engineering, mutagenesis, mapping and maintenance of mutations, and identification of mutant genes in the mouse. In this mini-review, many of these powerful techniques will be presented along with their application to the study of development, physiology, and disease.

phenotype; genome


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