Journal of Applied Physiology
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J Appl Physiol 94: 2384-2390, 2003. First published January 31, 2003; doi:10.1152/japplphysiol.00758.2002
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Vol. 94, Issue 6, 2384-2390, June 2003

Assessment of exhaled nitric oxide kinetics in healthy infants

T. Martínez1, A. Weist1, T. Williams1, C. Clem1, P. Silkoff2, and R. S. Tepper1

1 Department of Pediatric Pulmonology and Critical Care, Indiana University Medical Center, Indianapolis, Indiana 46202; and 2 Department of Medicine, National Jewish Medical and Research Center, Denver, Colorado 80206

Exhaled nitric oxide (FENO) measurements provide a noninvasive approach to the evaluation of airway inflammation. Flow-independent NO exchange parameters [airway NO transfer factor (DNO) and airway wall NO concentration (CwNO)] can be estimated from FENO measurements at low flows and may elucidate mechanisms of disturbances in NO exchange. We measured FENO in sedated infants by using an adaptation of a raised lung volume rapid thoracic compression technique that creates forced expiration through a mass-flow controller that lasts 5-10 s, at a constant preset flow. We measured FENO at expired flows of 50, 25, and 15 ml/s in five healthy infants (7-31 mo). Median FENO increased [24, 40, and 60 parts per billion (ppb)] with decreasing expiratory flows (50, 25, and 15 ml/s). Group median (range) for DNO and CwNO were 12.7 (3.2-37) × 10-3 nl · s-1 · ppb-1 and 108.9 (49-385) ppb, respectively, similar to values reported in healthy adults. Exhaled NO is flow dependent; flow-independent parameters of exhaled NO kinetics can be assessed in infants and are similar to values described in adults.

airway inflammation; lung function; nitric oxide measurement


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