Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 94: 2330-2336, 2003. First published February 21, 2003; doi:10.1152/japplphysiol.00790.2002
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
94/6/2330    most recent
00790.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (9)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Crandall, C. G.
Right arrow Articles by Levine, B. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Crandall, C. G.
Right arrow Articles by Levine, B. D.
Vol. 94, Issue 6, 2330-2336, June 2003

Prolonged head-down tilt exposure reduces maximal cutaneous vasodilator and sweating capacity in humans

C. G. Crandall1,2, M. Shibasaki1, T. E. Wilson1, J. Cui1, and B. D. Levine1,2

1 Institute for Exercise and Environmental Medicine at Presbyterian Hospital of Dallas, Dallas 75231; and 2 Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 73235

Cutaneous vasodilation and sweat rate are reduced during a thermal challenge after simulated and actual microgravity exposure. The effects of microgravity exposure on cutaneous vasodilator capacity and on sweat gland function are unknown. The purpose of this study was to test the hypothesis that simulated microgravity exposure, using the 6° head-down tilt (HDT) bed rest model, reduces maximal forearm cutaneous vascular conductance (FVC) and sweat gland function and that exercise during HDT preserves these responses. To test these hypotheses, 20 subjects were exposed to 14 days of strict HDT bed rest. Twelve of those subjects exercised (supine cycle ergometry) at 75% of pre-bed rest heart rate maximum for 90 min/day throughout HDT bed rest. Before and after HDT bed rest, maximal FVC was measured, via plethysmography, by heating the entire forearm to 42°C for 45 min. Sweat gland function was assessed by administering 1 × 10-6 to 2 M acetylcholine (9 doses) via intradermal microdialysis while simultaneously monitoring sweat rate over the microdialysis membranes. In the nonexercise group, maximal FVC and maximal stimulated sweat rate were significantly reduced after HDT bed rest. In contrast, these responses were unchanged in the exercise group. These data suggest that 14 days of simulated microgravity exposure, using the HDT bed rest model, reduces cutaneous vasodilator and sweating capacity, whereas aerobic exercise training during HDT bed rest preserves these responses.

thermoregulation; spaceflight; microdialysis; skin blood flow; deconditioning


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
M. J. Buono, R. Claros, T. DeBoer, and J. Wong
Na+ secretion rate increases proportionally more than the Na+ reabsorption rate with increases in sweat rate
J Appl Physiol, October 1, 2008; 105(4): 1044 - 1048.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. A. Radek, L. A. Baer, J. Eckhardt, L. A. DiPietro, and C. E. Wade
Mechanical unloading impairs keratinocyte migration and angiogenesis during cutaneous wound healing
J Appl Physiol, May 1, 2008; 104(5): 1295 - 1303.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Demiot, F. Dignat-George, J.-O. Fortrat, F. Sabatier, C. Gharib, I. Larina, G. Gauquelin-Koch, R. Hughson, and M.-A. Custaud
WISE 2005: chronic bed rest impairs microcirculatory endothelium in women
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3159 - H3164.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. Shibasaki, T. E. Wilson, and C. G. Crandall
Neural control and mechanisms of eccrine sweating during heat stress and exercise
J Appl Physiol, May 1, 2006; 100(5): 1692 - 1701.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
C. J. Gore, W. G. Hopkins, and C. M. Burge
Errors of measurement for blood volume parameters: a meta-analysis
J Appl Physiol, November 1, 2005; 99(5): 1745 - 1758.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. J. Mueller, C. M. Foley, and E. M. Hasser
Hindlimb unloading alters nitric oxide and autonomic control of resting arterial pressure in conscious rats
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2005; 289(1): R140 - R147.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. L. Davis, T. E. Wilson, J. M. Vener, C. G. Crandall, J. H. Petajan, and A. T. White
Pilocarpine-induced sweat gland function in individuals with multiple sclerosis
J Appl Physiol, May 1, 2005; 98(5): 1740 - 1744.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.