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J Appl Physiol 94: 2068-2083, 2003; doi:10.1152/japplphysiol.01029.2002
8750-7587/03 $5.00
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Vol. 94, Issue 5, 2068-2083, May 2003

HIGHLIGHTED TOPICS
Genetic Models in Applied Physiology
Invited Review: Effect of oxygen deprivation on cell cycle activity: a profile of delay and arrest

R. M. Douglas1 and G. G. Haddad1,2

1 Division of Respiratory Medicine, Department of Pediatrics and 2 Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461

One of the most fascinating fields that have emanated in the past few decades is developmental biology. This is not only the case from a research point of view but also from the angle of clinical care and treatment strategies. It is now well demonstrated that there are many diseases (some believe all diseases) that have their roots in embryogenesis or in early life, where nature and environment often team up to facilitate the genesis of disease. There is probably no better example to illustrate the interactions between nature and environment than in early life, as early as in the first several cell cycles. As will be apparent in this review, the cell cycle is a very regulated activity and this regulation is genetic in nature, with checkpoint proteins playing an important role in controlling the timing, the size, and the growth of daughter cells. However, it is also very clear, as will be discussed in this work, that the microenvironment of the first dividing cells is so important for the outcome of the organism. In this review, we will focus on the effect of one stress, that of hypoxia, on the young embryo and its cell division and growth. We will first review some of the cell cycle definitions and stages and then review briefly our current knowledge and its gaps in this area.

animal models; anoxia; cell division; cancer


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