Journal of Applied Physiology Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 94: 1949-1954, 2003. First published January 10, 2003; doi:10.1152/japplphysiol.00783.2002
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
94/5/1949    most recent
00783.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (12)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Reix, P.
Right arrow Articles by Praud, J.-P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Reix, P.
Right arrow Articles by Praud, J.-P.
Vol. 94, Issue 5, 1949-1954, May 2003

Active glottal closure during central apneas limits oxygen desaturation in premature lambs

Philippe Reix1, Julie Arsenault1, Valérie Dôme2, Pierre-Hugues Fortier3, Joëlle Rouillard Lafond1, François Moreau-Bussière1, Dominique Dorion3, and Jean-Paul Praud1,3

Departments of 1 Pediatrics and Physiology, 2 Gynecology and Obstetrics, and 3 Surgery (Ear, Nose, and Throat), Pulmonary Research Unit, University of Sherbrooke, Québec, Canada J1H 5N4

Our laboratory previously reported that active glottal closure was present in 90% of spontaneous central apneas in premature lambs while maintaining a high-apneic lung volume (Renolleau S, Letourneau P, Niyonsenga T, and Praud JP. Am J Respir Crit Care Med 159: 1396-1404, 1999.) The present study aimed at testing whether this mechanism limits postapnea oxygen desaturation. Four premature lambs were instrumented for recording states of alertness, thyroarytenoid muscle and diaphragm electromyographic (EMG) activity, nasal airflow, lung volume changes, and pulse oximetry. One thousand four hundred fifty-two spontaneous central apneas (isolated or during periodic breathing) were analyzed in nonsedated lambs. Apneas, with high lung volume maintained by active glottal closure, were compared with apneas, with a tracheostomy opened at apnea onset. Oxygen desaturation slopes were lower when high-apneic lung volume was actively maintained during both wakefulness and quiet sleep. Furthermore, oxygen desaturation slopes were lower after isolated apneas with continuous thyroarytenoid EMG during wakefulness, compared with apneas with noncontinuous thyroarytenoid EMG (= glottis opened shortly after apnea onset). These results highlight the importance of maintaining high-alveolar oxygen stores during central apneas by active glottal closure to limit desaturation in newborns.

larynx; sleep; lung volume; polysomnography


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. Duvareille, M. Lafrance, N. Samson, M. St-Hilaire, P. Pladys, P. Micheau, V. Bournival, C. Langlois, and J.-P. Praud
Effects of hypoxia and hypercapnia on nonnutritive swallowing in newborn lambs
J Appl Physiol, October 1, 2007; 103(4): 1180 - 1188.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I-J. Lu, K.-Z. Lee, and J.-C. Hwang
Capsaicin-induced activation of pulmonary vagal C fibers produces reflex laryngeal closure in the rat
J Appl Physiol, October 1, 2006; 101(4): 1104 - 1112.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. St-Hilaire, E. Nsegbe, K. Gagnon-Gervais, N. Samson, F. Moreau-Bussiere, P.-H. Fortier, and J.-P. Praud
Laryngeal chemoreflexes induced by acid, water, and saline in nonsedated newborn lambs during quiet sleep
J Appl Physiol, June 1, 2005; 98(6): 2197 - 2203.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
I-J. Lu, K.-Z. Lee, J.-T. Lin, and J.-C. Hwang
Capsaicin administration inhibits the abducent branch but excites the thyroarytenoid branch of the recurrent laryngeal nerves in the rat
J Appl Physiol, May 1, 2005; 98(5): 1646 - 1652.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. Reix, J. Arsenault, C. Langlois, T. Niyonsenga, and J.-P. Praud
Nonnutritive swallowing and respiration relationships in preterm lambs
J Appl Physiol, October 1, 2004; 97(4): 1283 - 1290.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online