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1 Noll Physiological Research Center, 2 Department of Kinesiology, The Pennsylvania State University, University Park, 16802-6900; and 3 Division of Cardiology, Department of Medicine, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033-0850
The purpose of the
present study was to test the hypothesis that leg blood flow
responses during submaximal cycle ergometry are reduced with age in
healthy normally active men. Eleven younger (20-25 yr) and eight
older (62-73 yr) normotensive, nonendurance-trained men performed
both graded and constant-load bouts of leg cycling at the same absolute
and relative [% of peak O2 consumption
(
O2 peak)] exercise intensities
while leg blood flow (femoral vein thermodilution), mean arterial
pressure (MAP; radial artery), cardiac output (acetylene rebreathing),
blood O2 content, and plasma catecholamines were measured.
Leg blood flow responses at the same absolute submaximal power outputs
(20-100 W) and at a fixed systemic O2 demand (1.1 l/min) did not differ between groups (P = 0.14-0.19), despite lower absolute levels of cardiac output in the
older men (P < 0.05). MAP at the same absolute power
outputs was 8-12 mmHg higher (P < 0.05) in the
older men, but calculated leg vascular conductance responses (leg blood
flow/MAP) were identical in the two groups (P > 0.9).
At the same relative intensity (60% O2
peak), leg norepinephrine spillover rates were approximately
twofold higher in the older men (P = 0.38).
Exercise-induced increases in leg arterial-venous O2
difference were identical between groups (P > 0.9)
because both arterial and venous O2 contents were lower in
the older vs. younger men. These results suggest that the ability to
augment active limb blood flow and O2 extraction during
submaximal large muscle mass exercise is not impaired but is well
preserved with age in healthy men who are normally active.
aging; exercise; cardiac output; oxygen extraction; catecholamines
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