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J Appl Physiol 94: 1821-1828, 2003. First published January 24, 2003; doi:10.1152/japplphysiol.00930.2002
8750-7587/03 $5.00
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Vol. 94, Issue 5, 1821-1828, May 2003

Canine model of nasal congestion and allergic rhinitis

Ruslan L. Tiniakov1, Olga P. Tiniakova1, Robbie L. McLeod2, John A. Hey2, and Donovan B. Yeates1

1 University of Illinois at Chicago, and Veterans Affairs Chicago Health Care System, Chicago, Illinois 60612; and 2 Schering-Plough Research Institute, Kenilworth, New Jersey 07033

The ragweed- and histamine-induced decreases in nasal patency in cohorts of ragweed-sensitized and nonsensitized dogs were assessed. The volume of nasal airways (VNA) was assessed by acoustic rhinometry and resistance to airflow (RNA) by anterior rhinomanometry. Histamine delivered to the nasal passages of five dogs caused a rapid and prolonged increase in RNA (0.75 ± 0.26 to 3.56 ± 0.50 cmH2O · l-1 · min), an effect that was reversed by intranasal delivery of aerosolized phenylephrine. Ragweed challenge in five ragweed-sensitized dogs increased RNA from 0.16 ± 0.02 to 0.53 ± 0.07 cmH2O · l-1 · min and decreased VNA from 12.5 ± 1.9 to 3.9 ± 0.3 cm3, whereas administration of saline aerosol neither increased RNA nor decreased VNA. Prior administration of D-pseudoephedrine (30 mg po) attenuated the ragweed-induced increase in RNA and decrease in VNA. Ragweed challenge changed neither RNA nor VNA in four nonsensitized dogs. Mediator-induced nasal congestion and allergen-induced allergic rhinitis in ragweed-sensitized dogs, which exhibit symptoms similar to human disease, can be used in the evaluation of safety and efficacy of antiallergic activity of potential drugs.

ragweed; histamine; alpha -adrenergic agonist; nasal resistance; acoustic rhinometry


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N. Skorohod and D. B. Yeates
Superoxide dismutase failed to attenuate allergen-induced nasal congestion in ragweed-sensitized dogs
J Appl Physiol, April 1, 2005; 98(4): 1478 - 1486.
[Abstract] [Full Text] [PDF]


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