Journal of Applied Physiology Millar Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 94: 1726-1734, 2003. First published January 17, 2003; doi:10.1152/japplphysiol.01152.2002
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
94/5/1726    most recent
01152.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (22)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Williamson, J. W.
Right arrow Articles by Mathews, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Williamson, J. W.
Right arrow Articles by Mathews, D.
Vol. 94, Issue 5, 1726-1734, May 2003

Evidence for central command activation of the human insular cortex during exercise

J. W. Williamson1, R. McColl2, and D. Mathews2

Departments of 1 Health Care Sciences, Physical Therapy, and 2 Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-8876

The purpose of this investigation was to determine whether central command activated regions of the insular cortex, independent of muscle metaboreflex activation and blood pressure elevations. Subjects (n = 8) were studied during 1) rest with cuff occlusion, 2) static handgrip exercise (SHG) sufficient to increase mean blood pressure (MBP) by 15 mmHg, and 3) post-SHG exercise cuff occlusion (PECO) to sustain the 15-mmHg blood pressure increase. Data were collected for heart rate, MBP, ratings of perceived exertion and discomfort, and regional cerebral blood flow (rCBF) by using single-photon-emission computed tomography. When time periods were compared when MBP was matched during SHG and PECO, heart rate (7 ± 3 beats/min; P < 0.05) and ratings of perceived exertion (15 ± 2 units; P < 0.05) were higher for SHG. During SHG, there were significant increases in rCBF for hand sensorimotor (9 ± 3%), right inferior posterior insula (7 ± 3%), left inferior anterior insula (8 ± 2%), and anterior cingluate regions (6 ± 2%), not found during PECO. There was significant activation of the inferior (ventral) thalamus and right inferior anterior insular for both SHG and PECO. Although prior studies have shown that regions of the insular cortex can be activated independent of mechanoreflex input, it was not presently assessed. These findings provide evidence that there are rCBF changes within regions of the insular and anterior cingulate cortexes related to central command per se during handgrip exercise, independent of metaboreflex activation and blood pressure elevation.

brain imaging; single-photon emission computed tomography; magnetic resonance imaging; autonomic control; brain mapping


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
L. C. Vianna, C. G. S. Araujo, and J. P. Fisher
Influence of central command and muscle afferent activation on anterior cerebral artery blood velocity responses to calf exercise in humans
J Appl Physiol, October 1, 2009; 107(4): 1113 - 1120.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
A. White, J. Lee, A. Light, and K. Light
Brain activation in multiple sclerosis: a BOLD fMRI study of the effects of fatiguing hand exercise
Multiple Sclerosis, May 1, 2009; 15(5): 580 - 586.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
S. W. Wong, D. S. Kimmerly, N. Masse, R. S. Menon, D. F. Cechetto, and J. K. Shoemaker
Sex differences in forebrain and cardiovagal responses at the onset of isometric handgrip exercise: a retrospective fMRI study
J Appl Physiol, October 1, 2007; 103(4): 1402 - 1411.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. S. Kimmerly, S. W. Wong, D. Salzer, R. Menon, and J. K. Shoemaker
Forebrain regions associated with postexercise differences in autonomic and cardiovascular function during baroreceptor unloading
Am J Physiol Heart Circ Physiol, July 1, 2007; 293(1): H299 - H306.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. A. Gray, P. Taggart, P. M. Sutton, D. Groves, D. R. Holdright, D. Bradbury, D. Brull, and H. D. Critchley
A cortical potential reflecting cardiac function
PNAS, April 17, 2007; 104(16): 6818 - 6823.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
J. W Williamson, P. J Fadel, and J. H Mitchell
New insights into central cardiovascular control during exercise in humans: a central command update
Exp Physiol, January 1, 2006; 91(1): 51 - 58.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
A. von Leupoldt and B. Dahme
Cortical Substrates for the Perception of Dyspnea
Chest, July 1, 2005; 128(1): 345 - 354.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. W. Williamson, R. McColl, and D. Mathews
Changes in regional cerebral blood flow distribution during postexercise hypotension in humans
J Appl Physiol, February 1, 2004; 96(2): 719 - 724.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online