| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center; 2 Section of Cardiology, Department of Medicine, Dartmouth-Hitchcock Medical Center and Dartmouth School of Medicine, Lebanon, New Hampshire 03756; and 3 Division of Cardiology, Department of Medicine, Durham Veterans Administration and Duke University Medical Center, Durham, North Carolina 27710
"Therapeutic angiogenesis" describes an emerging field of cardiovascular medicine whereby new blood vessels are induced to grow to supply oxygen and nutrients to ischemic cardiac or skeletal muscle. Various methods of producing therapeutic angiogenesis have been employed, including mechanical means, gene therapy, and the use of growth factors, among others. The use of appropriate large-animal models is essential if these therapies are to be critically evaluated in a preclinical setting before their use in humans, yet little has been written comparing the various available models. Over the past decade, swine have been increasingly used in studies of chronic ischemia because of their numerous similarities to humans, including minimal preexisting coronary collaterals as well as similar coronary anatomy and physiology. Consequently, this review describes the most commonly used swine models of chronic myocardial ischemia with special attention to regional myocardial blood flow and function and critically evaluates the strengths and weaknesses of each model in terms of utility for preclinical trials of angiogenic therapies.
coronary disease; animal models; myocardial ischemia; hibernation
This article has been cited by other articles:
|
|
 |
|
  S.G. Nekolla, S. Reder, A. Saraste, T. Higuchi, G. Dzewas, A. Preissel, M. Huisman, T. Poethko, T. Schuster, M. Yu, et al. Evaluation of the Novel Myocardial Perfusion Positron-Emission Tomography Tracer 18F-BMS-747158-02: Comparison to 13N-Ammonia and Validation With Microspheres in a Pig Model Circulation, May 5, 2009; 119(17): 2333 - 2342. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gnecchi, Z. Zhang, A. Ni, and V. J. Dzau Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy Circ. Res., November 21, 2008; 103(11): 1204 - 1219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Sinusas Targeted imaging offers advantages over physiological imaging for evaluation of angiogenic therapy. J. Am. Coll. Cardiol. Img., July 1, 2008; 1(4): 511 - 514. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Saeed, D. Saloner, A. Martin, L. Do, O. Weber, P. C. Ursell, A. Jacquier, R. Lee, and C. B. Higgins Adeno-associated Viral Vector-Encoding Vascular Endothelial Growth Factor Gene: Effect on Cardiovascular MR Perfusion and Infarct Resorption Measurements in Swine Radiology, May 1, 2007; 243(2): 451 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Schneider, K. Jaquet, R. Malisius, S. Geidel, E. Bahlmann, S. Boczor, T. Rau, M. Antz, K.-H. Kuck, and K. Krause Attenuation of cardiac remodelling by endocardial injection of erythropoietin: ultrasonic strain-rate imaging in a model of hibernating myocardium Eur. Heart J., February 2, 2007; 28(4): 499 - 509. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S Kassab Biomechanics of the cardiovascular system: the aorta as an illustratory example J R Soc Interface, December 22, 2006; 3(11): 719 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. T. Krause, K. Jaquet, S. Geidel, C. Schneider, C. Mandel, H.-P. Stoll, K. Hertting, T. Harle, and K.-H. Kuck Percutaneous endocardial injection of erythropoietin: Assessment of cardioprotection by electromechanical mapping Eur J Heart Fail, August 1, 2006; 8(5): 443 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Werner, M. Fritzenwanger, D. Prochnau, G. Schwarz, M. Ferrari, W. Aarnoudse, N. H.J. Pijls, and H. R. Figulla Determinants of Coronary Steal in Chronic Total Coronary Occlusions: Donor Artery, Collateral, and Microvascular Resistance J. Am. Coll. Cardiol., July 4, 2006; 48(1): 51 - 58. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Maratea, P. W. Snyder, and G. W. Stevenson Vascular lesions in nine gottingen minipigs with thrombocytopenic purpura syndrome. Vet. Pathol., July 1, 2006; 43(4): 447 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Choy, Q. Dang, S. Molloi, and G. S. Kassab Nonuniformity of axial and circumferential remodeling of large coronary veins in response to ligation Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1558 - H1565. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Horvath, C. Y. J. Lu, E. Robert, G. F. Pierce, R. Greene, B. A. Sosnowski, and J. Doukas Improvement of myocardial contractility in a porcine model of chronic ischemia using a combined transmyocardial revascularization and gene therapy approach J. Thorac. Cardiovasc. Surg., May 1, 2005; 129(5): 1071 - 1077. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. H. Annex and M. Simons Growth factor-induced therapeutic angiogenesis in the heart: protein therapy Cardiovasc Res, February 15, 2005; 65(3): 649 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. S. Werner, E. Jandt, A. Krack, G. Schwarz, O. Mutschke, F. Kuethe, M. Ferrari, and H. R. Figulla Growth Factors in the Collateral Circulation of Chronic Total Coronary Occlusions: Relation to Duration of Occlusion and Collateral Function Circulation, October 5, 2004; 110(14): 1940 - 1945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. E. Waters, R. L. Terjung, K. G. Peters, and B. H. Annex Preclinical models of human peripheral arterial occlusive disease: implications for investigation of therapeutic agents J Appl Physiol, August 1, 2004; 97(2): 773 - 780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Rutanen, T. T. Rissanen, J. E. Markkanen, M. Gruchala, P. Silvennoinen, A. Kivela, A. Hedman, M. Hedman, T. Heikura, M.-R. Orden, et al. Adenoviral Catheter-Mediated Intramyocardial Gene Transfer Using the Mature Form of Vascular Endothelial Growth Factor-D Induces Transmural Angiogenesis in Porcine Heart Circulation, March 2, 2004; 109(8): 1029 - 1035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. C. Hughes, S. S. Biswas, B. Yin, R. E. Coleman, T. R. DeGrado, C. K Landolfo, J. E. Lowe, B. H. Annex, and K. P. Landolfo Therapeutic angiogenesis in chronically ischemic porcine myocardium: comparative effects of bFGF and VEGF Ann. Thorac. Surg., March 1, 2004; 77(3): 812 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Ohtsuka, K. Ishikawa, S. Suzuki, I. Yamaguchi, N. Masuda, K. Wada, and W. Uchid A porcine model of ischemic heart failure produced by chronic placement of a tube in a coronary artery Eur J Heart Fail, October 1, 2003; 5(5): 591 - 598. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
