| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Jackson Laboratory, Bar Harbor, Maine 04609
The mouse is a proven model for studying human disease. Many strains exist that exhibit either natural or engineered genetic variation and thereby enable the elucidation of pathways involved in the development of cardiovascular disease. Although those mouse models have been fundamental to advancing our knowledge base, we are still at an early stage in understanding how genes contribute to complex disorders. There remains a need for new animal models that closely represent human disease. To expedite their development, we have established the Center for New Mouse Models of Heart, Lung, Blood, and Sleep Disorders at The Jackson Laboratory. We are using a phenotype-driven approach to identify mutations leading to atherosclerosis, hypertension, obesity, blood disorders, lung dysfunction, thrombosis, and disordered sleep. Our high-throughput, comprehensive phenotyping draws from two sources for new models: 1) the natural variation among over 40 inbred mouse strains and 2) chemically induced, whole-genome mutagenized mice. Here, we review our cardiovascular screens and present some hypertensive, obese, and cardiovascular models identified with this approach.
mutagenesis; Mouse Phenome Project
This article has been cited by other articles:
|
|
 |
|
  K. L. Svenson, N. Ahituv, R. S. Durgin, H. Savage, P. A. Magnani, O. Foreman, B. Paigen, and L. L. Peters A new mouse mutant for the LDL receptor identified using ENU mutagenesis J. Lipid Res., November 1, 2008; 49(11): 2452 - 2462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. D. Abel, S. E. Litwin, and G. Sweeney Cardiac Remodeling in Obesity Physiol Rev, April 1, 2008; 88(2): 389 - 419. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.P.F Flint and J.A Woolliams Precision animal breeding Phil Trans R Soc B, February 12, 2008; 363(1491): 573 - 590. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Svenson, R. Von Smith, P. A. Magnani, H. R. Suetin, B. Paigen, J. K. Naggert, R. Li, G. A. Churchill, and L. L. Peters Multiple trait measurements in 43 inbred mouse strains capture the phenotypic diversity characteristic of human populations J Appl Physiol, June 1, 2007; 102(6): 2369 - 2378. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Y. Polotsky Mouse model of the metabolic syndrome: the quest continues J Appl Physiol, June 1, 2007; 102(6): 2088 - 2089. [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. Pack, R. J. Galante, G. Maislin, J. Cater, D. Metaxas, S. Lu, L. Zhang, R. V. Smith, T. Kay, J. Lian, et al. Novel method for high-throughput phenotyping of sleep in mice Physiol Genomics, January 17, 2007; 28(2): 232 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kurc, D. A. Janies, A. D. Johnson, S. Langella, S. Oster, S. Hastings, F. Habib, T. Camerlengo, D. Ervin, U. V. Catalyurek, et al. An XML-based System for Synthesis of Data from Disparate Databases J. Am. Med. Inform. Assoc., May 1, 2006; 13(3): 289 - 301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lydic Sleep disruption is related to allelic variation in the ob gene Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R892 - R893. [Full Text] [PDF]
|
|
|
|
|
|
J. Wang, C. Einarsson, C. Murphy, P. Parini, I. Bjorkhem, M. Gafvels, and G. Eggertsen Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice J. Lipid Res., February 1, 2006; 47(2): 421 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. van den Bos, B. M. E. Mees, M. C. de Waard, R. de Crom, and D. J. Duncker A novel model of cryoinjury-induced myocardial infarction in the mouse: a comparison with coronary artery ligation Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1291 - H1300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Yu, Y. Shen, B. Chatterjee, B. H. Siegfried, L. Leatherbury, J. Rosenthal, J. F. Lucas, A. Wessels, C. F. Spurney, Y.-J. Wu, et al. ENU induced mutations causing congenital cardiovascular anomalies Development, December 15, 2004; 131(24): 6211 - 6223. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Korstanje and K. DiPetrillo Unraveling the genetics of chronic kidney disease using animal models Am J Physiol Renal Physiol, September 1, 2004; 287(3): F347 - F352. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. W. McBride, F. J. Charchar, D. Graham, W. H. Miller, P. Strahorn, F. J. Carr, and A. F. Dominiczak Functional genomics in rodent models of hypertension J. Physiol., January 1, 2004; 554(1): 56 - 63. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
