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J Appl Physiol 94: 1619-1626, 2003. First published December 13, 2002; doi:10.1152/japplphysiol.00040.2002
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Vol. 94, Issue 4, 1619-1626, April 2003

Cardiovascular and splenic responses to exercise in humans

Ian B. Stewart1, Darren E. R. Warburton1,2, Alastair N. H. Hodges1, Donald M. Lyster2, and Donald C. McKenzie1,2

1 School of Human Kinetics and 2 Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4

To investigate splenic erythrocyte volume after exercise and the effect on hematocrit- and hemoglobin-based plasma volume equations, nine men cycled at an intensity of 60% maximal O2 uptake for 5-, 10-, or 15-min duration, followed by an incremental ride to exhaustion. The reduction in spleen volume, calculated using 99mTc-labeled erythrocytes, was not significantly different among the three submaximal rides (5 min = 28%, 10 min = 30%, 15 min = 36%; P = 0.26). The incremental ride to exhaustion resulted in a 56% reduction in spleen volume, which recovered to baseline levels within 20 min. Plasma catecholamines were inversely related to spleen volume after exercise (r = 0.70-0.84; P < 0.0001). There were no differences in red cell or total blood volume pre- to postexercise; however, a significant reduction in plasma volume was observed (18.9%; P < 0.01). There was no difference between the iodinated albumin and the hematocrit and hemoglobin methods of assessing plasma volume changes. These results suggest that the spleen regulates its volume in response to an intensity-dependent signal, and plasma catecholamines appear partially responsible. Splenic release of erythrocytes has no effect on indirect measures of plasma volume.

spleen; plasma volume; hematocrit; hemoglobin; plasma catecholamines


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