Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 94: 1431-1436, 2003. First published December 6, 2002; doi:10.1152/japplphysiol.00825.2002
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
94/4/1431    most recent
00825.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (4)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schmitt, P. M.
Right arrow Articles by Kaufman, M. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schmitt, P. M.
Right arrow Articles by Kaufman, M. P.
Vol. 94, Issue 4, 1431-1436, April 2003

High concentrations of 17beta -estradiol attenuate the exercise pressor reflex in male cats

Petra M. Schmitt and Marc P. Kaufman

Departments of Internal Medicine and Human Physiology, Division of Cardiovascular Medicine, University of California, Davis, California 95616

Previously, intravenous injection of 17beta -estradiol in decerebrate male cats was found to attenuate central command but not the exercise pressor reflex. This latter finding was surprising because the dorsal horn, the spinal site receiving synaptic input from thin-fiber muscle afferents, is known to contain estrogen receptors. We were prompted, therefore, to reexamine this issue. Instead of injecting 17beta -estradiol intravenously, we applied it topically to the L7 and S1 spinal cord of male decerebrate cats. We found that topical application (150-200 µl) of 17beta -estradiol in concentrations of 0.01, 0.1, and 1 µg/ml had no effect on the exercise pressor reflex, whereas a concentration of 10 µg/ml attenuated the reflex. We conclude that, in male cats, estrogen can only attenuate the exercise pressor reflex in concentrations that exceed the physiological level.

estrogen; neural control of circulation; thin fiber muscle afferents; control of breathing; spinal cord; dorsal horn


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
S. W. Wong, D. S. Kimmerly, N. Masse, R. S. Menon, D. F. Cechetto, and J. K. Shoemaker
Sex differences in forebrain and cardiovagal responses at the onset of isometric handgrip exercise: a retrospective fMRI study
J Appl Physiol, October 1, 2007; 103(4): 1402 - 1411.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. M. Schmitt, K. Gohil, and M. P. Kaufman
Spinal estrogen attenuates the exercise pressor reflex but has little effect on the expression of genes regulating neurotransmitters in the dorsal root ganglia
J Appl Physiol, March 1, 2006; 100(3): 958 - 964.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. M. Schmitt and M. P. Kaufman
Estrogen's attenuating effect on the exercise pressor reflex is more opioid dependent in gonadally intact than in ovariectomized female cats
J Appl Physiol, February 1, 2005; 98(2): 633 - 639.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
P. M. Schmitt and M. P. Kaufman
Estrogen attenuates the exercise pressor reflex in female cats
J Appl Physiol, October 1, 2003; 95(4): 1418 - 1424.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online