Journal of Applied Physiology AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 94: 1335-1344, 2003. First published November 15, 2002; doi:10.1152/japplphysiol.00457.2002
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
94/4/1335    most recent
00457.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pott, F.
Right arrow Articles by Secher, N. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pott, F.
Right arrow Articles by Secher, N. H.
Vol. 94, Issue 4, 1335-1344, April 2003

Middle cerebral artery blood velocity during intense static exercise is dominated by a Valsalva maneuver

Frank Pott1, Johannes J. Van Lieshout3, Kojiro Ide1, Per Madsen1, and Niels H. Secher1,2

1 The Copenhagen Muscle Research Center and 2 Department of Anesthesia, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen, Denmark; and 3 Department of Medicine, Academic Medical Center, University of Amsterdam, 1100 DE Amsterdam, The Netherlands

Lifting of a heavy weight may lead to "blackout" and occasionally also to cerebral hemorrhage, indicating pronounced consequences for the blood flow through the brain. We hypothesized that especially strenuous respiratory straining (a Valsalva-like maneuver) associated with intense static exercise would lead to a precipitous rise in mean arterial and central venous pressures and, in turn, influence the middle cerebral artery blood velocity (MCA Vmean) as a noninvasive indicator of changes in cerebral blood flow. In 10 healthy subjects, MCA Vmean was evaluated in response to maximal static two-legged exercise performed either with a concomitantly performed Valsalva maneuver or with continued ventilation and also during a Valsalva maneuver without associated exercise (n = 6). During static two-legged exercise, the largest rise for mean arterial pressure and MCA Vmean was established at the onset of exercise performed with a Valsalva-like maneuver (by 42 ± 5 mmHg and 31 ± 3% vs. 22 ± 6 mmHg and 25 ± 6% with continued ventilation; P < 0.05). Profound reductions in MCA Vmean were observed both after exercise with continued ventilation (-29 ± 4% together with a reduction in the arterial CO2 tension by -5 ± 1 Torr) and during the maintained Valsalva maneuver (-21 ± 3% together with an elevation in central venous pressure to 40 ± 7 mmHg). Responses to performance of the Valsalva maneuver with and without exercise were similar, reflecting the deterministic importance of the Valsalva maneuver for the central and cerebral hemodynamic response to intense static exercise. Continued ventilation during intense static exercise may limit the initial rise in arterial pressure and may in turn reduce the risk of hemorrhage. On the other hand, blackout during and after intense static exercise may reflect a reduction in cerebral blood flow due to expiratory straining and/or hyperventilation.

cerebral perfusion pressure; mean blood velocity; near infrared spectroscopy; subarachnoid aneurysmal hemorrhage; weight lifting


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. Brondum, J. M. Hasenkam, N. H. Secher, M. F. Bertelsen, C. Grondahl, K. K. Petersen, R. Buhl, C. Aalkjaer, U. Baandrup, H. Nygaard, et al.
Jugular venous pooling during lowering of the head affects blood pressure of the anesthetized giraffe
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2009; 297(4): R1058 - R1065.
[Abstract] [Full Text] [PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
J. C. Barton, L. F. Bertoli, and S. O'Malley
Bilateral Subdural Hematomas in an Adult With Hereditary Factor VII Deficiency: A Complication of Sit-ups and Inversion?
Clinical and Applied Thrombosis/Hemostasis, April 1, 2009; 15(2): 242 - 244.
[Abstract] [PDF]

Home page
 J. Appl. Physiol.Home page
N. H. Secher, T. Seifert, and J. J. Van Lieshout
Cerebral blood flow and metabolism during exercise: implications for fatigue
J Appl Physiol, January 1, 2008; 104(1): 306 - 314.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
L. W. J Bogert and J. J van Lieshout
Non-invasive pulsatile arterial pressure and stroke volume changes from the human finger
Exp Physiol, July 1, 2005; 90(4): 437 - 446.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
N. van Dijk, I. G. J. M. de Bruin, J. Gisolf, H. A. C. M. R. de Bruin-Bon, M. Linzer, J. J. van Lieshout, and W. Wieling
Hemodynamic effects of leg crossing and skeletal muscle tensing during free standing in patients with vasovagal syncope
J Appl Physiol, February 1, 2005; 98(2): 584 - 590.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online