Journal of Applied Physiology AJP: Gastrointestinal and Liver Physiology
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J Appl Physiol 94: 991-996, 2003. First published October 4, 2002; doi:10.1152/japplphysiol.00746.2001
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Vol. 94, Issue 3, 991-996, March 2003

Acetazolamide reduces exercise capacity and increases leg fatigue under hypoxic conditions

Luke A. Garske, Michael G. Brown, and Stephen C. Morrison

Department of Thoracic Medicine, Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia

Acetazolamide (Acz) is used at altitude to prevent acute mountain sickness, but its effect on exercise capacity under hypoxic conditions is uncertain. Nine healthy men completed this double-blind, randomized, crossover study. All subjects underwent incremental exercise to exhaustion with an inspired O2 fraction of 0.13, hypoxic ventilatory responses, and hypercapnic ventilatory responses after Acz (500 mg twice daily for 5 doses) and placebo. Maximum power of 203 ± 38 (SD) W on Acz was less than the placebo value of 225 ± 40 W (P < 0.01). At peak exercise, arterialized capillary pH was lower and PO2 higher on Acz (P < 0.01). Ventilation was 118.6 ± 20.0 l/min at the maximal power on Acz and 102.4 ± 20.7 l/min at the same power on placebo (P < 0.02), and Borg score for leg fatigue was increased on Acz (P < 0.02), with no difference in Borg score for dyspnea. Hypercapnic ventilatory response on Acz was greater (P < 0.02), whereas hypoxic ventilatory response was unchanged. During hypoxic exercise, Acz reduced exercise capacity associated with increased perception of leg fatigue. Despite increased ventilation, dyspnea was not increased.

control of breathing; hypoxia; acidosis


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