Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 94: 975-982, 2003. First published November 15, 2002; doi:10.1152/japplphysiol.00619.2002
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
94/3/975    most recent
00619.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (21)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bailey, T. C.
Right arrow Articles by Veldhuizen, R. A. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bailey, T. C.
Right arrow Articles by Veldhuizen, R. A. W.
Vol. 94, Issue 3, 975-982, March 2003

High oxygen concentrations predispose mouse lungsto the deleterious effects of high stretch ventilation

Timothy C. Bailey1, Erica L. Martin1, Lin Zhao2, and Ruud A. W. Veldhuizen1,3

1 Departments of Physiology and Pharmacology, 2 Obstetrics and Gynaecology, and 3 Medicine, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada N6A 4V2

Mechanical ventilation is a necessary intervention for patients with acute lung injury. However, mechanical ventilation can propagate acute lung injury and increase systemic inflammation. The exposure to >21% oxygen is often associated with mechanical ventilation yet has not been examined within the context of lung stretch. We hypothesized that mice exposed to >90% oxygen will be more susceptible to the deleterious effects of high stretch mechanical ventilation. C57B1/6 mice were randomized into 48-h exposure of 21 or >90% oxygen; mice were then killed, and isolated lungs were randomized into a nonstretch or an ex vivo, high-stretch mechanical ventilation group. Lungs were assessed for compliance and lavaged for surfactant analysis, and cytokine measurements or lungs were homogenized for surfactant-associated protein analysis. Mice exposed to >90% oxygen + stretch had significantly lower compliance, altered pulmonary surfactant, and increased inflammatory cytokines compared with all other groups. Our conclusion is that 48 h of >90% oxygen and high-stretch mechanical ventilation deleteriously affect lung function to a greater degree than stretch alone.

pulmonary surfactant; inflammatory cytokines


This article has been cited by other articles:


Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. L. Martin, T. A. Sheikh, K. J. Leco, J. F. Lewis, and R. A. W. Veldhuizen
Contribution of alveolar macrophages to the response of the TIMP-3 null lung during a septic insult
Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L779 - L789.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
L. P. Desai, S. E. Sinclair, K. E. Chapman, A. Hassid, and C. M. Waters
High tidal volume mechanical ventilation with hyperoxia alters alveolar type II cell adhesion
Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L769 - L778.
[Abstract] [Full Text] [PDF]

Home page
 Biophys. JHome page
E. Keating, L. Rahman, J. Francis, A. Petersen, F. Possmayer, R. Veldhuizen, and N. O. Petersen
Effect of Cholesterol on the Biophysical and Physiological Properties of a Clinical Pulmonary Surfactant
Biophys. J., August 15, 2007; 93(4): 1391 - 1401.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. L. Martin, L. A. McCaig, B. Z. Moyer, M. C. Pape, K. J. Leco, J. F. Lewis, and R. A. W. Veldhuizen
Differential response of TIMP-3 null mice to the lung insults of sepsis, mechanical ventilation, and hyperoxia
Am J Physiol Lung Cell Mol Physiol, August 1, 2005; 289(2): L244 - L251.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. C. Bailey, K. A. Da Silva, J. F. Lewis, K. Rodriguez-Capote, F. Possmayer, and R. A. W. Veldhuizen
Physiological and inflammatory response to instillation of an oxidized surfactant in a rat model of surfactant deficiency
J Appl Physiol, May 1, 2004; 96(5): 1674 - 1680.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. L. Martin, B. Z. Moyer, M. C. Pape, B. Starcher, K. J. Leco, and R. A. W. Veldhuizen
Negative impact of tissue inhibitor of metalloproteinase-3 null mutation on lung structure and function in response to sepsis
Am J Physiol Lung Cell Mol Physiol, December 1, 2003; 285(6): L1222 - L1232.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online