Journal of Applied Physiology AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 94: 876-882, 2003. First published November 1, 2002; doi:10.1152/japplphysiol.00766.2002
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
94/3/876    most recent
00766.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (10)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McLoughlin, T. J.
Right arrow Articles by Pizza, F. X.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McLoughlin, T. J.
Right arrow Articles by Pizza, F. X.
Vol. 94, Issue 3, 876-882, March 2003

Inflammatory cells in rat skeletal muscle are elevated after electrically stimulated contractions

Thomas J. McLoughlin1,*, Eleni Mylona1,*, Troy A. Hornberger2, Karyn A. Esser2, and Francis X. Pizza1

1 Department of Kinesiology, The University of Toledo, Toledo, Ohio 43606; and 2 School of Kinesiology, University of Illinois, Chicago, Illinois 60608

We determined the effect of muscle contractions resulting from high-frequency electrical stimulation (HFES) on inflammatory cells in rat tibialis anterior (TA), plantaris (Pln), and soleus (Sol) muscles at 6, 24, and 72 h post-HFES. A minimum of four and a maximum of seven rats were analyzed at each time point. HFES, applied to the sciatic nerve, caused the Sol and Pln to contract concentrically and the TA to contract eccentrically. Neutrophils were higher (P < 0.05) at 6 and 24 h after HFES in the Sol, Pln, and TA muscles relative to control muscles. ED1+ macrophages in the Pln were elevated at 6 and 24 h after HFES and were also elevated in the Sol and TA after HFES relative to controls. ED2+ macrophages in the Sol and TA were elevated at 24 and 72 h after HFES, respectively, and were also elevated in the Pln after HFES relative to controls. In contrast to the TA muscles, the Pln and Sol muscles showed no gross histological abnormalities. Collectively, these data indicate that both eccentric and concentric contractions can increase inflammatory cells in muscle, regardless of whether overt histological signs of injury are apparent.

muscle injury; inflammation; neutrophils; ED1 macrophages; ED2 macrophages

* T. J. McLoughlin and E. Mylona contributed equally to this work.




This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
F. X. Pizza, B. C. Clark, R. E. De Meersman, S. M. Phillips, N. Stupka, S. Sipila, V. Kovanen, H. Suominen, G. L. Warren, D. A. Lowe, et al.
Comments on Point:Counterpoint: Estrogen and sex do/do not influence post-exercise indexes of muscle damage, inflammation, and repair
J Appl Physiol, March 1, 2009; 106(3): 1016 - 1020.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. Peterson and F. X. Pizza
Cytokines derived from cultured skeletal muscle cells after mechanical strain promote neutrophil chemotaxis in vitro
J Appl Physiol, January 1, 2009; 106(1): 130 - 137.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. M. Peterson, K. D. Feeback, J. H. Baas, and F. X. Pizza
Tumor necrosis factor-{alpha} promotes the accumulation of neutrophils and macrophages in skeletal muscle
J Appl Physiol, November 1, 2006; 101(5): 1394 - 1399.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. K. Tsivitse, E. Mylona, J. M. Peterson, W. T. Gunning, and F. X. Pizza
Mechanical loading and injury induce human myotubes to release neutrophil chemoattractants
Am J Physiol Cell Physiol, March 1, 2005; 288(3): C721 - C729.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
F. X Pizza, J. M Peterson, J. H Baas, and T. J Koh
Neutrophils contribute to muscle injury and impair its resolution after lengthening contractions in mice
J. Physiol., February 1, 2005; 562(3): 899 - 913.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. H. S. Chan, A. L. Carey, M. J. Watt, and M. A. Febbraio
Cytokine gene expression in human skeletal muscle during concentric contraction: evidence that IL-8, like IL-6, is influenced by glycogen availability
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2004; 287(2): R322 - R327.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. Brickson, L. L. Ji, K. Schell, R. Olabisi, B. St. Pierre Schneider, and T. M. Best
M1/70 attenuates blood-borne neutrophil oxidants, activation, and myofiber damage following stretch injury
J Appl Physiol, September 1, 2003; 95(3): 969 - 976.
[Abstract] [Full Text] [PDF]

Home page
 Journals of Gerontology Series A: Biological Sciences and Medical SciencesHome page
T. J. Koh, J. M. Peterson, F. X. Pizza, and S. V. Brooks
Passive Stretches Protect Skeletal Muscle of Adult and Old Mice From Lengthening Contraction-Induced Injury
J. Gerontol. A Biol. Sci. Med. Sci., July 1, 2003; 58(7): B592 - 597.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online