Journal of Applied Physiology AJP: Regulatory, Integrative and Comparative Physiology
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J Appl Physiol 94: 1269-1278, 2003. First published November 27, 2002; doi:10.1152/japplphysiol.00858.2002
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Vol. 94, Issue 3, 1269-1278, March 2003

HIGHLIGHTED TOPICS
Plasticity in Respiratory Motor Control
Selected Contribution: Peripheral chemoreflex function in high-altitude natives and patients with chronic mountain sickness

Fabiola León-Velarde1, Alfredo Gamboa1, Maria Rivera-Ch1, Jose-Antonio Palacios1, and Peter A. Robbins2

1 Departmento De Ciencias Biologicas y Fisiologicas/IIA, Universidad Peruana Cayetano Heredia, Lima 100, Peru; and 2 University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom

Peripheral chemoreflex function was studied in high-altitude (HA) natives at HA, in patients with chronic mountain sickness (CMS) at HA, and in sea-level (SL) natives at SL. Results were as follows. 1) Acute ventilatory responses to hypoxia (AHVR) in the HA and CMS groups were approximately one-third of those of the SL group. 2) In CMS patients, some indexes of AHVR were modestly, but significantly, lower than in healthy HA natives. 3) Prior oxygenation increased AHVR in all subject groups. 4) Neither low-dose dopamine nor somatostatin suppressed any component of ventilation that could not be suppressed by acute hyperoxia. 5) In all subject groups, the ventilatory response to hyperoxia was biphasic. Initially, ventilation fell but subsequently rose so that, by 20 min, ventilation was higher in hyperoxia than hypoxia for both HA and CMS subjects. 6) Peripheral chemoreflex stimulation of ventilation was modestly greater in HA and CMS subjects at an end-tidal PO2 = 52.5 Torr than in SL natives at an end-tidal PO2 = 100 Torr. 7) For the HA and CMS subjects combined, there was a strong correlation between end-tidal PCO2 and hematocrit, which persisted after controlling for AHVR.

regulation of ventilation; hypoxic ventilatory response; human; Andean natives; hyperoxia; dopamine; somatostatin; blunting


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