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J Appl Physiol 94: 1263-1268, 2003. First published November 27, 2002; doi:10.1152/japplphysiol.00857.2002
8750-7587/03 $5.00
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Vol. 94, Issue 3, 1263-1268, March 2003

HIGHLIGHTED TOPICS
Plasticity in Respiratory Motor Control
Selected Contribution: High-altitude natives living at sea level acclimatize to high altitude like sea-level natives

Maria Rivera-Ch1, Alfredo Gamboa1, Fabiola León-Velarde1, Jose-Antonio Palacios1, David F. O'Connor2, and Peter A. Robbins2

1 Departmento De Ciencias Biologicas y Fisiologicas/IIA, Universidad Peruana Cayetano Heredia, Lima 100, Peru; and 2 University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom

Sea-level (SL) natives acclimatizing to high altitude (HA) increase their acute ventilatory response to hypoxia (AHVR), but HA natives have values for AHVR below those for SL natives at SL (blunting). HA natives who live at SL retain some blunting of AHVR and have more marked blunting to sustained (20-min) hypoxia. This study addressed the question of what happens when HA natives resident at SL return to HA: do they acclimatize like SL natives or revert to the characteristics of HA natives? Fifteen HA natives resident at SL were studied, together with 15 SL natives as controls. Air-breathing end-tidal PCO2 and AHVR were determined at SL. Subjects were then transported to 4,300 m, where these measurements were repeated on each of the following 5 days. There were no significant differences in the magnitude or time course of the changes in end-tidal PCO2 and AHVR between the two groups. We conclude that HA natives normally resident at SL undergo ventilatory acclimatization to HA in the same manner as SL natives.

regulation of ventilation; human; Andean natives; chemoreflex; blunting




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