Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 94: 1242-1252, 2003; doi:10.1152/japplphysiol.00715.2002
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (16)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morris, K. F.
Right arrow Articles by Lindsey, B. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morris, K. F.
Right arrow Articles by Lindsey, B. G.
Vol. 94, Issue 3, 1242-1252, March 2003

HIGHLIGHTED TOPICS
Plasticity in Respiratory Motor Control
Invited Review: Neural network plasticity in respiratory control

K. F. Morris1, D. M. Baekey1, S. C. Nuding1, T. E. Dick2, R. Shannon1, and B. G. Lindsey1

1 Department of Physiology and Biophysics, University of South Florida Health Sciences Center, Tampa, Florida 33612; and 2 Departments of Medicine, Pharmacology, and Neurosciences, Case Western Reserve University and University Hospitals Research Institute, Cleveland, Ohio 44106

Respiratory network plasticity is a modification in respiratory control that persists longer than the stimuli that evoke it or that changes the behavior produced by the network. Different durations and patterns of hypoxia can induce different types of respiratory memories. Lateral pontine neurons are required for decreases in respiratory frequency that follow brief hypoxia. Changes in synchrony and firing rates of ventrolateral and midline medullary neurons may contribute to the long-term facilitation of breathing after brief intermittent hypoxia. Long-term changes in central respiratory motor control may occur after spinal cord injury, and the brain stem network implicated in the production of the respiratory rhythm could be reconfigured to produce the cough motor pattern. Preliminary analysis suggests that elements of brain stem respiratory neural networks respond differently to hypoxia and hypercapnia and interact with areas involved in cardiovascular control. Plasticity or alterations in these networks may contribute to the chronic upregulation of sympathetic nerve activity and hypertension in sleep apnea syndrome and may also be involved in sudden infant death syndrome.

raphe; ventral respiratory group; hypoxia; memory; cough


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
I. A. Rybak, R. O'Connor, A. Ross, N. A. Shevtsova, S. C. Nuding, L. S. Segers, R. Shannon, T. E. Dick, W. L. Dunin-Barkowski, J. M. Orem, et al.
Reconfiguration of the Pontomedullary Respiratory Network: A Computational Modeling Study With Coordinated In Vivo Experiments
J Neurophysiol, October 1, 2008; 100(4): 1770 - 1799.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y.-H. Hsieh, T. E. Dick, and R. E. Siegel
Adaptation to hypobaric hypoxia involves GABAA receptors in the pons
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R549 - R557.
[Abstract] [Full Text] [PDF]

Home page
 Neural Comput.Home page
J. E. Dayhoff
Computational properties of networks of synchronous groups of spiking neurons.
Neural Comput., September 1, 2007; 19(9): 2433 - 2467.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
A. Kepecs, N. Uchida, and Z. F. Mainen
Rapid and Precise Control of Sniffing During Olfactory Discrimination in Rats
J Neurophysiol, July 1, 2007; 98(1): 205 - 213.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
S. Mahamed and G. S. Mitchell
Sleep Apnoea & Hypertension: Physiological bases for a causal relation: Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea?
Exp Physiol, January 1, 2007; 92(1): 27 - 37.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
G. E. Foster, M. J. Poulin, and P. J. Hanly
Sleep Apnoea & Hypertension: Physiological bases for a causal relation: Intermittent hypoxia and vascular function: implications for obstructive sleep apnoea
Exp Physiol, January 1, 2007; 92(1): 51 - 65.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online