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J Appl Physiol 94: 1033-1038, 2003. First published November 27, 2002; doi:10.1152/japplphysiol.00879.2002
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Vol. 94, Issue 3, 1033-1038, March 2003

Reduced exercise arteriovenous O2 difference in Type 2 diabetes

James C. Baldi1, James L. Aoina1, Helen C. Oxenham2, Warwick Bagg2, and Robert N. Doughty2

Departments of 1 Sport and Exercise Science and 2 Cardiovascular Research, School of Medicine, University of Auckland, Auckland, New Zealand

Maximal O2 consumption (VO2 max) is lower in individuals with Type 2 diabetes than in sedentary nondiabetic individuals. This study aimed to determine whether the lower VO2 max in diabetic patients was due to a reduction in maximal cardiac output (Qmax) and/or peripheral O2 extraction. After 11 Type 2 diabetic patients and 12 nondiabetic subjects, matched for age and body composition, who had not exercised for 2 yr, performed a bicycle ergometer exercise test to determine VO2 max, submaximal cardiac output, Qmax, and arterial-mixed venous O2 (a-<A><AC>v</AC><AC>&cjs1171;</AC></A> O2) difference were assessed. Maximal workload, VO2 max, and maximal a-<A><AC>v</AC><AC>&cjs1171;</AC></A> O2 difference were lower in Type 2 diabetic patients (P < 0.05). Qmax was low in both groups but not significantly different: 11.2 and 10.0 l/min for controls and diabetic patients, respectively (P > 0.05). Submaximal O2 uptake and heart rate were lower at several workloads in diabetic patients; respiratory exchange ratio was similar between groups at all workloads. VO2 max was linearly correlated with a-<A><AC>v</AC><AC>&cjs1171;</AC></A> O2 difference, but not Qmax in diabetic patients. These data suggest that a reduction in maximal a-<A><AC>v</AC><AC>&cjs1171;</AC></A> O2 difference contributes to a decreased VO2 max in Type 2 diabetic patients.

maximal aerobic capacity; cardiac output


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