Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 94: 642-650, 2003. First published October 18, 2002; doi:10.1152/japplphysiol.00656.2002
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
94/2/642    most recent
00656.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (15)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Allen, M. R.
Right arrow Articles by Bloomfield, S. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Allen, M. R.
Right arrow Articles by Bloomfield, S. A.
Vol. 94, Issue 2, 642-650, February 2003

Hindlimb unloading has a greater effect on cortical compared with cancellous bone in mature female rats

Matthew R. Allen and Susan A. Bloomfield

Department of Health and Kinesiology, Texas A&M University, College Station, Texas 77843-4243

This study was designed to determine the effects of 28 days of hindlimb unloading (HU) on the mature female rat skeleton. In vivo proximal tibia bone mineral density and geometry of HU and cage control (CC) rats were measured with peripheral quantitative computed tomography (pQCT) on days 0 and 28. Postmortem pQCT, histomorphometry, and mechanical testing were performed on tibiae and femora. After 28 days, HU animals had significantly higher daily food consumption (+39%) and lower serum estradiol levels (-49%, P = 0.079) compared with CC. Proximal tibia bone mineral content and cortical bone area significantly declined over 28 days in HU animals (-4.0 and 4.8%, respectively), whereas total and cancellous bone mineral densities were unchanged. HU animals had lower cortical bone formation rates and mineralizing surface at tibial midshaft, whereas differences in similar properties were not detected in cancellous bone of the distal femur. These results suggest that cortical bone, rather than cancellous bone, is more prominently affected by unloading in skeletally mature retired breeder female rats.

bone mineral density; simulated microgravity; peripheral quantitative computed tomography, histomorphometry; mechanical properties


This article has been cited by other articles:


Home page
 Endocr. Rev.Home page
A. E. Kearns, S. Khosla, and P. J. Kostenuik
Receptor Activator of Nuclear Factor {kappa}B Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease
Endocr. Rev., April 1, 2008; 29(2): 155 - 192.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Baek, A. A. Barlow, M. R. Allen, and S. A. Bloomfield
Food restriction and simulated microgravity: effects on bone and serum leptin
J Appl Physiol, April 1, 2008; 104(4): 1086 - 1093.
[Abstract] [Full Text] [PDF]

Home page
 Poult. Sci.Home page
W. K. Kim, L. M. Donalson, S. A. Bloomfield, H. A. Hogan, L. F. Kubena, D. J. Nisbet, and S. C. Ricke
Molt Performance and Bone Density of Cortical, Medullary, and Cancellous Bone in Laying Hens During Feed Restriction or Alfalfa-Based Feed Molt
Poult. Sci., September 1, 2007; 86(9): 1821 - 1830.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
V. David, M.-H. Lafage-Proust, N. Laroche, A. Christian, P. Ruegsegger, and L. Vico
Two-week longitudinal survey of bone architecture alteration in the hindlimb-unloaded rat model of bone loss: sex differences
Am J Physiol Endocrinol Metab, March 1, 2006; 290(3): E440 - E447.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
J. C. L. Tou, S. B. Arnaud, R. Grindeland, and C. Wade
The Effect of Purified Compared with Nonpurified Diet on Bone Changes Induced by Hindlimb Suspension of Female Rats
Experimental Biology and Medicine, January 1, 2005; 230(1): 31 - 39.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online