Journal of Applied Physiology Journal of Neurophysiology
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J Appl Physiol 94: 93-100, 2003. doi:10.1152/japplphysiol.00341.2002
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Vol. 94, Issue 1, 93-100, January 2003

Medullary raphe neuron activity is altered during fictive cough in the decerebrate cat

David M. Baekey1, Kendall F. Morris1,2, Sarah C. Nuding1, Lauren S. Segers1, Bruce G. Lindsey1,2, and Roger Shannon1,2

1 Department of Physiology and Biophysics and 2 Neuroscience Program, University of South Florida Health Sciences Center, Tampa, Florida 33612-4799

Chemical lesions in the medullary raphe nuclei region influence cough. This study examined whether firing patterns of caudal medullary midline neurons were altered during cough. Extracellular neuron activity was recorded with microelectrode arrays in decerebrated, neuromuscular-blocked, ventilated cats. Cough-like motor patterns (fictive cough) in phrenic and lumbar nerves were elicited by mechanical stimulation of the intrathoracic trachea. Discharge patterns of respiratory and nonrespiratory-modulated neurons were altered during cough cycles (58/133); 45 increased and 13 decreased activity. Fourteen cells changed firing rate during the inspiratory and/or expiratory phases of cough. Altered patterns in 43 cells were associated with the duration of, or extended beyond, the cough episodes. The different response categories suggest that multiple factors influence the discharge patterns during coughing: e.g., respiratory-modulated and tonic inputs and intrinsic connections. These results suggest involvement of midline neurons (i.e., raphe nuclei) in the cough reflex.

control of breathing; brain stem respiratory network; neural plasticity


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