Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 94: 20-30, 2003. First published September 20, 2002; doi:10.1152/japplphysiol.00898.2001
8750-7587/03 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
94/1/20    most recent
00898.2001v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (11)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ingenito, E. P.
Right arrow Articles by Reilly, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ingenito, E. P.
Right arrow Articles by Reilly, J. J.
Vol. 94, Issue 1, 20-30, January 2003

Physiological characterization of variability in response to lung volume reduction surgery

Edward P. Ingenito1, Stephen H. Loring3, Marilyn L. Moy1, Steven J. Mentzer2, Scott J. Swanson2, and John J. Reilly1

Division of 1 Pulmonary and Critical Care Medicine and 2 Thoracic Surgery, Brigham and Women's Hospital, and 3 Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115

This paper examines potential physiological mechanisms responsible for improvement after lung volume reduction surgery (LVRS). In 25 patients (63 ± 9 yr; 11 men, 14 women), spirometry [forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC)], lung volumes [residual volume (RV) and total lung capacity (TLC)], small airway resistance, recoil pressures, and respiratory muscle contractility (RMC) were measured before and 4-6 mo after LVRS. Data were interpreted to assess how changes in each component of lung mechanics affect overall function. Among responders (Delta FEV1 >=  12%; 150 ml), improvement was primarily due to an increase in FVC, not to FEV1-to-FVC ratio. Among nonresponders, FEV1, FVC, and RV/TLC did not change after surgery, although recoil pressure increased in both groups. Both groups experienced a reduction in RMC after LVRS. In conclusion, LVRS improves function in emphysema by resizing the lung relative to the chest wall by reducing RV. LVRS does not change airway resistance but decreases RMC, which attenuates the potential benefits of LVRS that are generated by reducing RV/TLC. Among nonresponders, recoil pressure increased out of proportion to reduced volume, such that no increase in vital capacity or improvement in FEV1 occurred.

lung volume reduction; emphysema; lung mechanics; lung volumes


This article has been cited by other articles:


Home page
 Proc Am Thorac SocHome page
H. E. Fessler, S. M. Scharf, E. P. Ingenito, R. J. McKenna Jr., and A. Sharafkhaneh
Physiologic Basis for Improved Pulmonary Function after Lung Volume Reduction
Proceedings of the ATS, May 1, 2008; 5(4): 416 - 420.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
G. R. Washko, E. Hoffman, and J. J. Reilly
Radiographic Evaluation of the Potential Lung Volume Reduction Surgery Candidate
Proceedings of the ATS, May 1, 2008; 5(4): 421 - 426.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
F. Tacconi, E. Pompeo, D. Forcella, M. Marino, D. Varvaras, and T. C. Mineo
Lung Volume Reduction Reoperations
Ann. Thorac. Surg., April 1, 2008; 85(4): 1171 - 1177.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Cazzola, W. MacNee, F. J. Martinez, K. F. Rabe, L. G. Franciosi, P. J. Barnes, V. Brusasco, P. S. Burge, P. M. A. Calverley, B. R. Celli, et al.
Outcomes for COPD pharmacological trials: from lung function to biomarkers
Eur. Respir. J., February 1, 2008; 31(2): 416 - 469.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
J. A. Falk, U. J. Martin, S. Scharf, and G. J. Criner
Lung Elastic Recoil Does Not Correlate With Pulmonary Hemodynamics in Severe Emphysema
Chest, November 1, 2007; 132(5): 1476 - 1484.
[Abstract] [Full Text] [PDF]

Home page
 Proc Am Thorac SocHome page
D. E. O'Donnell
Hyperinflation, dyspnea, and exercise intolerance in chronic obstructive pulmonary disease.
Proceedings of the ATS, January 1, 2006; 3(2): 180 - 184.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
R. B. Gorman, D. K. McKenzie, J. E. Butler, J. F. Tolman, and S. C. Gandevia
Diaphragm Length and Neural Drive after Lung Volume Reduction Surgery
Am. J. Respir. Crit. Care Med., November 15, 2005; 172(10): 1259 - 1266.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. Ost, L. Glassman, A. M. Fein, and P. Marcus
Innovations in Lung Volume Reduction: The Non-Cutting Edge
Chest, July 1, 2004; 126(1): 6 - 9.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
M. Decramer
Treatment of chronic respiratory failure: lung volume reduction surgery versus rehabilitation
Eur. Respir. J., November 16, 2003; 22(47_suppl): 47S - 56s.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online