Journal of Applied Physiology
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J Appl Physiol 94: 199-204, 2003; doi:10.1152/japplphysiol.00634.2002
8750-7587/03 $5.00
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Vol. 94, Issue 1, 199-204, January 2003

Middle ear pressure change during controlled breathing with gas mixtures containing nitrous oxide

William J. Doyle and Juliane M. Banks

Department of Pediatric Otolaryngology, Children's Hospital of Pittsburgh and the Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213

The change in middle ear pressure while breathing gas mixtures containing N2O was studied in four monkeys. At each of three experimental sessions, monkeys were anesthetized, acclimated for 60 min, breathed with room air for 60 min, and then breathed with 5, 10, or 20% N2O for 60 min. Middle ear pressure, rectal temperature, and vital signs were recorded throughout. The time constant for blood-middle ear N2O exchange was calculated from these data. Middle ear pressure decreased during acclimation, was stable during air breathing, and increased during N2O breathing. The rate of pressure change was similar for both ears of each animal and was directly related to N2O percent. The calculated time constant ranged from 0.003 to 0.008 min-1 across animals but was not different for a given ear across sessions. These results show that breathing gas mixtures containing N2O causes predictable and quantifiable increases in middle ear pressure.

time constant; animal model; gas exchange


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