Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 93: 2181-2191, 2002. First published August 30, 2002; doi:10.1152/japplphysiol.00313.2002
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
93/6/2181    most recent
00313.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (17)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Richard, J. C.
Right arrow Articles by Guerin, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Richard, J. C.
Right arrow Articles by Guerin, C.
Vol. 93, Issue 6, 2181-2191, December 2002

Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury

J. C. Richard, M. Janier, F. Lavenne, V. Berthier, D. Lebars, G. Annat, F. Decailliot, and C. Guerin

Service de Réanimation Médicale et Assistance Respiratoire, Lyon 69004; Equipe d'Accueil Universitaire 1896, Université Claude Bernard Lyon I, 69008 Lyon; Centre d'Exploration et de Recherche Médicales par Emission de Positons, Hôpital Neuro-Cardiologique, 69003 Lyon, France

In a porcine model of oleic acid-induced lung injury, the effects of inhaled nitric oxide (iNO) and intravenous almitrine bismesylate (ivALM), which enhances the hypoxic pulmonary vasoconstriction on the distribution of regional pulmonary blood flow (PBF), were assessed. After injection of 0.12 ml/kg oleic acid, 20 anesthetized and mechanically ventilated piglets [weight of 25 ± 2.6 (SD) kg] were randomly divided into four groups: supine position, prone position, and 10 ppm iNO for 40 min followed by 4 µg · kg-1 · min-1 ivALM for 40 min in supine position and in prone position. PBF was measured with positron emission tomography and H215O. The redistribution of PBF was studied on a pixel-by-pixel basis. Positron emission tomography scans were performed before and then 120, 160, and 200 min after injury. With prone position alone, although PBF remained prevalent in the dorsal regions it was significantly redistributed toward the ventral regions (P < 0.001). A ventral redistribution of PBF was also obtained with iNO regardless of the position (P = 0.043). Adjunction of ivALM had no further effect on PBF redistribution. PP and iNO have an additive effect on ventral redistribution of PBF.

prone position; oleic acid; pulmonary blood flow; positron emission tomography; inhaled nitric oxide


This article has been cited by other articles:


Home page
 ChestHome page
T. D. Girard and G. R. Bernard
Mechanical Ventilation in ARDS: A State-of-the-Art Review
Chest, March 1, 2007; 131(3): 921 - 929.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. S. Harris and D. P. Schuster
Visualizing lung function with positron emission tomography
J Appl Physiol, January 1, 2007; 102(1): 448 - 458.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
T. Silva-Costa-Gomes, L. Gallart, J. Valles, L. Trillo, J. Minguella, and M. M. Puig
Low- vs high-dose almitrine combined with nitric oxide to prevent hypoxia during open-chest one-lung ventilation
Br. J. Anaesth., September 1, 2005; 95(3): 410 - 416.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
T. Richter, G. Bellani, R. S. Harris, M. F. V. Melo, T. Winkler, J. G. Venegas, and G. Musch
Effect of Prone Position on Regional Shunt, Aeration, and Perfusion in Experimental Acute Lung Injury
Am. J. Respir. Crit. Care Med., August 15, 2005; 172(4): 480 - 487.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
J.-C. Richard, M. Janier, F. Lavenne, C. Tourvieille, D. Le Bars, N. Costes, G. Gimenez, and C. Guerin
Quantitative Assessment of Regional Alveolar Ventilation and Gas Volume Using 13N-N2 Washout and PET
J. Nucl. Med., August 1, 2005; 46(8): 1375 - 1383.
[Abstract] [Full Text] [PDF]

Home page
 JAMAHome page
C. Guerin, S. Gaillard, S. Lemasson, L. Ayzac, R. Girard, P. Beuret, B. Palmier, Q. V. Le, M. Sirodot, S. Rosselli, et al.
Effects of Systematic Prone Positioning in Hypoxemic Acute Respiratory Failure: A Randomized Controlled Trial
JAMA, November 17, 2004; 292(19): 2379 - 2387.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Crit. Care Med.Home page
M. Quintel, P. Pelosi, P. Caironi, J. P. Meinhardt, T. Luecke, P. Herrmann, P. Taccone, C. Rylander, F. Valenza, E. Carlesso, et al.
An Increase of Abdominal Pressure Increases Pulmonary Edema in Oleic Acid-induced Lung Injury
Am. J. Respir. Crit. Care Med., February 15, 2004; 169(4): 534 - 541.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online