Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 93: 2122-2128, 2002. First published September 6, 2002; doi:10.1152/japplphysiol.00676.2002
8750-7587/02 $5.00
This Article
Right arrow Full Text Free
Right arrow Full Text (PDF) Free
Right arrow All Versions of this Article:
93/6/2122    most recent
00676.2002v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via ISI Web of Science (7)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kavdia, M.
Right arrow Articles by Popel, A. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kavdia, M.
Right arrow Articles by Popel, A. S.
Vol. 93, Issue 6, 2122-2128, December 2002

Theoretical analysis of effects of blood substitute affinity and cooperativity on organ oxygen transport

Mahendra Kavdia1, Roland N. Pittman2, and Aleksander S. Popel1

1 Department of Biomedical Engineering, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205; and 2 Department of Physiology, Virginia Commonwealth University, Richmond, Virginia 23298

Hemoglobin-based O2 carriers (HBOCs), which are developed as an alternative to blood transfusion, provide O2 delivery. At present, there is no model to predict the O2 transport for a red blood cell-HBOC mixture on a whole organ basis. On the basis of the first principles of mass balance, a model of O2 transport for an organ was derived to calculate venous PO2 (PvO2) for a given inlet arterial PO2 (PaO2), blood flow, and oxygen consumption. The model was validated by using several in vivo animal studies on HBOC administration for a wide range of HBOC oxygen-binding parameters and predicted PvO2 for various PaO2 in the same species. The model was also used to predict the effect of HBOC affinity and cooperativity on PvO2 for humans. The results indicate that PvO2 can be increased at a constant blood flow-to-oxygen consumption ratio by reducing the affinity of HBOC for normoxia and mild hypoxia; however, a high-affinity HBOC would be more efficient in maintaining higher PvO2 for severe hypoxia (PaO2 < 40 Torr).

hemoglobin based oxygen carrier; oxygen affinity; exchange transfusion; partial pressure of oxygen at 50% hemoglobin saturation; oxygen dissociation curve; cat; hamster


This article has been cited by other articles:


Home page
 Canadian J. AnesthesiaHome page
G. M.T. Hare, A. Harrington, E. Liu, J. L. Wang, A. J. Baker, and C. D. Mazer
Effect of oxygen affinity and molecular weight of HBOCs on cerebral oxygenation and blood pressure in rats: [L'effet de l'affinite pour l'oxygene et du poids moleculaire des TOBH sur l'oxygenation et la tension arterielle chez les rats].
Can J Anesth, October 1, 2006; 53(10): 1030 - 1038.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Rebel, S. Cao, H. Kwansa, S. Dore, E. Bucci, and R. C. Koehler
Dependence of acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobin
Am J Physiol Heart Circ Physiol, March 1, 2006; 290(3): H1027 - H1037.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. O. Dull, B. J. DeWitt, R. Dinavahi, L. Schwartz, C. Hubert, N. Pace, and C. Fronticelli
Quantitative assessment of hemoglobin-induced endothelial barrier dysfunction
J Appl Physiol, November 1, 2004; 97(5): 1930 - 1937.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
G. M. T. Hare, K. M. Hum, S. Y. Kim, A. Barr, A. J. Baker, and C. D. Mazer
Increased Cerebral Tissue Oxygen Tension After Extensive Hemodilution with a Hemoglobin-Based Oxygen Carrier
Anesth. Analg., August 1, 2004; 99(2): 528 - 535.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Contaldo, S. Schramm, R. Wettstein, H. Sakai, S. Takeoka, E. Tsuchida, M. Leunig, A. Banic, and D. Erni
Improved oxygenation in ischemic hamster flap tissue is correlated with increasing hemodilution with Hb vesicles and their O2 affinity
Am J Physiol Heart Circ Physiol, August 7, 2003; 285(3): H1140 - H1147.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online