Journal of Applied Physiology AJP: Endocrinology and Metabolism
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J Appl Physiol 93: 2059-2069, 2002. First published August 30, 2002; doi:10.1152/japplphysiol.00446.2002
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Vol. 93, Issue 6, 2059-2069, December 2002

Dynamics of intramuscular 31P-MRS Pi peak splitting and the slow components of PCr and O2 uptake during exercise

H. B. Rossiter1,2, S. A. Ward3, F. A. Howe4, J. M. Kowalchuk5, J. R. Griffiths4, and B. J. Whipp1,3

Departments of 1 Physiology and 4 Biochemistry, St. George's Hospital Medical School, Tooting, London SW17 0RE; 3 Centre for Exercise Science and Medicine, University of Glasgow, Glasgow G12 8QQ, United Kingdom; 5 The Center for Activity and Ageing, School of Kinesiology, and Department of Physiology, The University of Western Ontario, London, Ontario, Canada, N6A 3K7; and 2 Department of Medicine, Division of Physiology, University of California, San Diego, CA, 92093-0623

The dynamics of pulmonary O2 uptake (VO2) during the on-transient of high-intensity exercise depart from monoexponentiality as a result of a "slow component" whose mechanisms remain conjectural. Progressive recruitment of glycolytic muscle fibers, with slow O2 utilization kinetics and low efficiency, has, however, been suggested as a mechanism. The demonstration of high- and low-pH components of the exercising skeletal muscle 31P magnetic resonance (MR) spectrum [inorganic phosphate (Pi) peak] at high work rates (thought to be reflective of differences between oxidative and glycolytic muscle fibers) is also consistent with this conjecture. We therefore investigated the dynamics of VO2 (using a turbine and mass spectrometry) and intramuscular ATP, phosphocreatine (PCr), and Pi concentrations and pH, estimated from the 31P MR spectrum. Eleven healthy men performed prone square-wave high-intensity knee extensor exercise in the bore of a whole body MR spectrometer. A VO2 slow component of magnitude 15.9 ± 6.9% of the phase II amplitude was accompanied by a similar response (11.9 ± 7.1%) in PCr concentration. Only five subjects demonstrated a discernable splitting of the Pi peak, however, which began from between 35 and 235 s after exercise onset and continued until cessation. As such, the dynamics of the pH distribution in intramuscular compartments did not consistently reflect the temporal features of the VO2 slow component, suggesting that Pi splitting does not uniquely reflect the activity of oxidative or glycolytic muscle fibers per se.

O2 uptake kinetics; magnetic resonance spectroscopy; exercise; intramuscular pH; Pi peak splitting; phosphocreatine


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