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J Appl Physiol 93: 2053-2058, 2002. First published September 6, 2002; doi:10.1152/japplphysiol.00490.2002
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Vol. 93, Issue 6, 2053-2058, December 2002

Effects of exercise and beta 2-agonists on lung function in chronic obstructive pulmonary disease

Angelo Corsico1, Paola Fulgoni1, Massimiliano Beccaria1, Maria Cristina Zoia1, Giovanni Barisione3, Riccardo Pellegrino2, Vito Brusasco3, and Isa Cerveri1

1 Laboratorio di Fisiopatologia Respiratoria, Clinica Malattie Apparato Respiratorio, Università di Pavia, Istituto di Ricovero e Cura a Carattere Scientifico Policlinico S. Matteo, 27100 Pavia; 2 Servizio di Fisiopatologia Respiratoria, Azienda Ospedaliera S. Croce e Carle, 12100 Cuneo; and 3 Fisiopatologia Respiratoria, Dipartimento di Medicina Interna, Università di Genova, 16132 Genoa, Italy

The effects of inhaled bronchodilators at rest and during exercise were studied in 15 subjects with chronic obstructive pulmonary disease. In a crossover study against placebo, albuterol caused a significant increase in expiratory flow and reduced lung hyperinflation and dyspnea at rest, but this was not associated with differences in symptoms with exercise or any relevant parameter of physical performance. Dynamic hyperinflation occurred during exercise similarly after placebo or albuterol and was associated with a reduction of forced expiratory flows. This, in turn, was correlated with the bronchoconstrictor effect of deep inhalation determined at rest. In a parallel group study, expiratory flow was increased by 3-wk treatment with salmeterol (n = 9) but not with placebo (n = 6). However, in neither group was the response to exercise different from baseline. These results suggest that in chronic obstructive pulmonary disease effective pharmacological bronchodilation at rest may not be predictive of benefits of exercise tolerance. This may be related to the occurrence of airway narrowing during exercise, particularly when a deep inhalation at rest is followed by a decrease in expiratory flow.

lung hyperinflation; maximal and partial flow-volume loops; deep inhalation; dyspnea


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